Results 81 to 90 of about 251,555 (277)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Backtracking and Mixing Rate of Diffusion on Uncorrelated Temporal Networks

Entropy, 2017
We consider the problem of diffusion on temporal networks, where the dynamics of each edge is modelled by an independent renewal process. Despite the apparent simplicity of the model, the trajectories of a random walker exhibit non-trivial properties ...
Martin Gueuning, Renaud Lambiotte, Jean-Charles Delvenne   +2 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Biased random walks on random graphs [PDF]

, 2014
These notes cover one of the topics programmed for the St Petersburg School in Probability and Statistical Physics of June 2012. The aim is to review recent mathematical developments in the field of random walks in random environment.
Arous, Gerard Ben, Fribergh, Alexander
core  

Critical dimensions for random walks on random-walk chains [PDF]

Physical Review E, 1996
The probability distribution of random walks on linear structures generated by random walks in $d$-dimensional space, $P_d(r,t)$, is analytically studied for the case $ \equiv r/t^{1/4}\ll1$. It is shown to obey the scaling form $P_d(r,t)= (r) t^{-1/2} ^{-2} f_d( )$, where $ (r)\sim r^{2-d}$ is the density of the chain.
Rabinovich S., Roman H. E., Havlin S., Bunde A.   +3 more
openaire   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Random walks with random velocities

Physical Review E, 2008
We consider a random walk model that takes into account the velocity distribution of random walkers. Random motion with alternating velocities is inherent to various physical and biological systems. Moreover, the velocity distribution is often the first characteristic that is experimentally accessible. Here, we derive transport equations describing the
Zaburdaev, V., Schmiedeberg, M., Stark, H.   +2 more
openaire   +4 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Random Search Walks Inside Absorbing Annuli

Entropy
We revisit the problem of random search walks in the two-dimensional (2D) space between concentric absorbing annuli, in which a searcher performs random steps until finding either the inner or the outer ring.
Anderson S. Bibiano-Filho, Jandson F. O. de Freitas, Marcos G. E. da Luz, Gandhimohan M. Viswanathan, Ernesto P. Raposo   +4 more
doaj   +1 more source

Discrete Random Walks on One-Sided ``Periodic'' Graphs [PDF]

Discrete Mathematics & Theoretical Computer Science, 2003
In this paper we consider discrete random walks on infinite graphs that are generated by copying and shifting one finite (strongly connected) graph into one direction and connecting successive copies always in the same way.
Michael Drmota
doaj   +1 more source