Results 71 to 80 of about 1,809,097 (279)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Backtracking and Mixing Rate of Diffusion on Uncorrelated Temporal Networks
Entropy, 2017 We consider the problem of diffusion on temporal networks, where the dynamics of each edge is modelled by an independent renewal process. Despite the apparent simplicity of the model, the trajectories of a random walker exhibit non-trivial properties ...
Martin Gueuning +2 more
doaj +1 more source
On Some Multivariate Distribution of Random Walks [PDF]
The Egyptian Statistical Journal, 1974 In this note we consider a probability scheme which can be interpreted a random walk with jumps which form a Poisson process. The scheme is tackled by solving some difference differential equation which appear in queueing theory.
Khairia El-Nadi
doaj +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Random Search Walks Inside Absorbing Annuli
EntropyWe revisit the problem of random search walks in the two-dimensional (2D) space between concentric absorbing annuli, in which a searcher performs random steps until finding either the inner or the outer ring.
Anderson S. Bibiano-Filho +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
Five Years of Continuous-time Random Walks in Econophysics [PDF]
This paper is a short review on the application of continuos-time random walks to Econophysics in the last five years.Duration; Continuous-time random walk; Fractional calculus; Statistical ...
Enrico Scalas
core
FEBS Open Bio, EarlyView.Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source