Results 131 to 140 of about 702,734 (359)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

The challenges faced in the design, conduct and analysis of surgical randomised trials [PDF]

, 2009
Randomised evaluations of surgical interventions are rare; some interventions have been widely adopted without rigorous evaluation. Unlike other medical areas, the randomised controlled trial (RCT) design has not become the default study design for the ...
Cook, Jonathan Alistair
core  

Study protocol: can a school gardening intervention improve children's diets? [PDF]

, 2012
BACKGROUND: The current academic literature suggests there is a potential for using gardening as a tool to improve children's fruit and vegetable intake.
A Demas, A Magarey, A Timperio, AW Fogarty, Birch, C Knai, Charlotte EL Evans, CL Perry, CL Perry, D Ciliska, D Gross, E Bere, E Bere, Foundation BN, G Auld, J Baranowski, J Connolly, J Gregory, J Rasbash, J Wardle, Janet E Cade, JD Skinner, JJ Reilly, JK Ransley, JO Fisher, Joan K Ransley, K Patrick, KD Reynolds, KW Cullen, KW Cullen, L Blanchette, L Wells, M Campbell, M Maynard, M Nelson, M Prelip, Mark Conner, Meaghan S Christian, MR Singer, MW Howerton, National Foundation for Educational Research, P Sahota, R Perera, S Somerset, S Somerset, SA French, SJ Te Velde, ST Yeo, StataCorp, World Cancer Research Fund, World Health Organization   +50 more
core   +2 more sources

Randomised controlled trial of interferon alfa (lymphoblastoid interferon) in chronic non-A non-B hepatitis. [PDF]

, 1989
M R Jacyna, Martin Brooks, R. H. Loke, Janice Main, Iain M. Murray‐Lyon, Howard C. Thomas   +5 more
openalex   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Zinc supplementation during pregnancy: a double blind randomised controlled trial. [PDF]

, 1989
Kassam Mahomed, David James, Jean Golding, R. McCabe   +3 more
openalex   +1 more source

Randomised controlled trials: important but overrated?

Journal of the Royal College of Physicians of Edinburgh, 2011
Practising physicians individualise treatments, hoping to achieve optimal outcomes by tackling relevant patient variables. The randomised controlled trial (RCT) is universally accepted as the best means of comparison. Yet doctors sometimes wonder if particular patients might benefit more from treatments that fared worse in the RCT comparisons.
Boylan, J, Kavanagh, B, Armitage, J
openaire   +4 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Impact of Social Stories on social and emotional health of autism spectrum primary school children: the ASSSIST2 RCT with economic evaluation

Health Technology Assessment
Background Differences in the way autistic children experience the world can contribute to anxiety and stress. Carol Gray’s Social Stories™ are a highly personalised intervention to support children by providing social information about specific ...
Barry Wright, Kerry Jane Bell, Jane E Blackwell, Catarina Teige, Laura Mandefield, Han I Wang, Charlie Welch, Arabella Scantlebury, Jude Watson, Dean McMillan, Emma Standley, Leah Attwell, Hayley Carrick, Amelia Taylor, Olivia Taylor, Rachel Hodkinson, Hannah Edwards, Hannah Pearson, Steve Parrott, David Marshall, Danielle Varley, Rebecca Hargate, Ann Mclaren, Catherine Elizabeth Hewitt   +23 more
doaj   +1 more source

Randomised controlled trials of phenobarbitone and valproate in febrile convulsions. [PDF]

, 1988
Richard Newton
openalex   +1 more source