Results 131 to 140 of about 760,498 (359)

Effect of ondansetron on spinal anesthesia-induced hypotension in non-obstetric surgeries: a randomised, double-blind and placebo-controlled trial

, 2021
Fabrício Tavares Mendonça, Luis Carlos Crepaldi, Rafaela Carvalho Gersanti, Kamila Christine de Araújo   +3 more
openalex   +1 more source

Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis: systematic review and meta-regression

, 2013
Background: Recent studies have shown a decrease in annualised relapse rates (ARRs) in placebo groups of randomised controlled trials (RCTs) in relapsing multiple sclerosis (RMS).
Friede, Tim, Nicholas, Richard, Röver, Christian, Schneider, Simon, Steinvorth, Simon M., Straube, Sebastian   +5 more
core   +1 more source

TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243] [PDF]

, 2002
Agitated or violent patients constitute 10% of all emergency psychiatric treatment. Management guidelines, the preferred treatment of clinicians and clinical practice all differ.
A Jablensky, B Thornley, CB Joy, Clive E Adams, E Coutinho, Evandro SF Coutinho, Expert Consensus Guideline Group, F Moritz, G Huf, Gisele Huf, HI Kaplan, J Ludbrook, JG Cunnane, LS Pilowsky, M Fenton, M Hotopf, M Wyant, P Armitage, RL Binder, The Royal College of Psychiatrists, VW Berger, Z Atakan   +21 more
core   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Oxytocin may be useful to increase trust in others and decrease disruptive behaviours in patients with Prader-Willi syndrome: a randomised placebo-controlled trial in 24 patients [PDF]

, 2011
M. Tauber, Carine Mantoulan, P. Copet, Joseba Jauregui, Geneviève Demeer, Gwénaëlle Diene, Bernadette Rogé, Virginie Laurier, Virginie Ehlinger, Catherine Arnaud, Catherine Molinas, Denise Thuilleaux   +11 more
openalex   +1 more source

Procedure time and filling quality for bulk-fill base and conventional incremental composite techniques—A randomised controlled in vitro trial

, 2023
K. Leinonen, Jukka Leinonen, Napat Bolstad, Tarja Tanner, Mohammed Al‐Haroni, Jan‐Are K. Johnsen   +5 more
openalex   +2 more sources

Targeted, structured text messaging to improve dietary and lifestyle behaviours for people on maintenance haemodialysis (KIDNEYTEXT): Study protocol for a randomised controlled trial [PDF]

, 2019
Introduction Managing nutrition is critical for reducing morbidity and mortality in patients on haemodialysis but adherence to the complex dietary restrictions remains problematic.
Brown, Mark, Campbell, Katrina L., Chow, Clara, Craig, Jonathan, Howard, Kirsten, Howell, Martin, Khalid, Rabia, Lee, Vincent W., Stevenson, Jessica, Sud, Kamal, Teixeira-Pinto, Armando, Thiagalingam, Aravinda, Tong, Allison   +12 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

On-demand use of tramadol, sildenafil, paroxetine and local anaesthetics for the management of premature ejaculation: A randomised placebo-controlled clinical trial [PDF]

, 2013
Tarek Gameel, A. Tawfik, Mohamed O. Abou-Farha, Mohamed G. Bastawisy, Mohamed Ahmed Elbendary, Abd El-naser K Elgamasy   +5 more
openalex   +1 more source

Prospective multicentre randomised controlled trial of the effect of Braun Enteroenterostomy in the Reconstruction after Pancreaticoduodenectomy on delayed gastric emptying (DGE): protocol for the BERP study [PDF]

, 2022
Saksham Gupta, Kai Brown, Natalie Lott, R. Carroll, David Burnett, Mehrdad Nikfarjam   +5 more
openalex   +1 more source