Results 61 to 70 of about 698,130 (312)

Supported employment: randomised controlled trial [PDF]

British Journal of Psychiatry, 2010
BackgroundThere is evidence from North American trials that supported employment using the individual placement and support (IPS) model is effective in helping individuals with severe mental illness gain competitive employment. There have been few trials in other parts of the world.AimsTo investigate the effectiveness and cost-effectiveness of IPS in ...
Howard, Louise M., Heslin, Margaret, Leese, Morven, McCrone, Paul, Rice, Christopher, Jarrett, Manuela, Spokes, Terry, Huxley, Peter, Thornicroft, Graham   +8 more
openaire   +4 more sources

Cognitive Functioning in Vorinostat‐Treated Pediatric and Young Adult Patients Over the First 180 Days After Hematopoietic Stem Cell Transplant

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Cognitive and psychological difficulties could negatively interfere with treatment adherence and quality of life before and after hematopoietic stem cell transplant (HSCT). Methods to mitigate these changes may have positive effects on treatment success.
Kristen L. Votruba, Michelle Rozwadowski, Thomas Braun, April Rahrig, Edward Peres, Kirsten M. Williams, Vanessa Fabrizio, Julie‐An Talano, Carrie L. Kitko, Nicolas Parnell, Pavan Reddy, Sung Won Choi   +11 more
wiley   +1 more source

Early antiviral treatment in outpatients with COVID-19 (FLARE): a structured summary of a study protocol for a randomised controlled trial

Trials, 2021
Objectives The objective of this trial is to assess whether early antiviral therapy in outpatients with COVID-19 with either favipiravir plus lopinavir/ritonavir, lopinavir/ritonavir alone, or favipiravir alone, is associated with a decrease in viral ...
Li-An K. Brown, Nick Freemantle, Judy Breuer, Hakim-Moulay Dehbi, Kashfia Chowdhury, Gemma Jones, Felicia Ikeji, Amalia Ndoutoumou, Krishneya Santhirakumar, Nicky Longley, Anna M. Checkley, Joseph F. Standing, David M. Lowe   +12 more
doaj   +1 more source

Establishing cost-effectiveness of genetic targeting of cancer therapies [PDF]

, 2011
The clinical benefit of a new genomic instrument, the 70-gene signature for breast cancer patients, is being evaluated in a randomised clinical trial. The early, controlled implementation process is supported by a Constructive Technology Assessment to ...
Harten, W.H. van, Joore, M.A., Retèl, Valesca P., Rutgers, E.J.Th.   +3 more
core   +1 more source

Larval therapy for leg ulcers (VenUS II) : randomised controlled trial [PDF]

, 2009
Objective To compare the clinical effectiveness of larval therapy with a standard debridement technique (hydrogel) for sloughy or necrotic leg ulcers. Design Pragmatic, three armed randomised controlled trial.
Bland, J. Martin, Cullum, Nicky, Dowson, Christopher G., Dumville, Jo C., HASH(0x55aa08b64cf0), Iglesias, Cynthia, Mitchell, Joanne L., Nelson, E. Andrea, Soares, Marta O., Torgerson, David J., Worthy, Gill   +10 more
core   +3 more sources

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Moxibustion for cephalic version: a feasibility randomised controlled trial

BMC Complementary and Alternative Medicine, 2011
Background Moxibustion (a type of Chinese medicine which involves burning a herb close to the skin) has been used to correct a breech presentation.
Bisits Andrew, Dahlen Hannah, Smith Caroline A, Do Carole K, Schmied Virginia   +4 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Randomised controlled trial of the Community Navigator programme to reduce loneliness and depression for adults with treatment-resistant depression in secondary community mental health services: trial protocol

Trials, 2023
Background New treatments are needed for people with treatment-resistant depression (TRD), who do not benefit from anti-depressants and many of whom do not recover fully with psychological treatments.
Theodora Stefanidou, Gareth Ambler, Gergely Bartl, Nick Barber, Jo Billings, Tumelo Bogatsu, Richard Carroll, Beverley Chipp, Maev Conneely, Anne-Marie Downey, Gamze Evlat, Rachael Hunter, Marie Le Novere, Glyn Lewis, Tanya Mackay, Steven Marwaha, Zubair Matin, Georgia Naughton, Chandani Nekitsing, Millie O’Sullivan, Vanessa Pinfold, Shengning Pan, Angela Sobers, Keith J. Thompson, Jerusaa Vasikaran, Martin Webber, Sonia Johnson, Brynmor Lloyd-Evans   +27 more
doaj   +1 more source

Recruiting ethnic minority participants to a clinical trial: a qualitative study [PDF]

, 2013
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non ...
Griffiths, C, Grigg, J, Macneill, V, Nwokoro, C, Seale, C   +4 more
core   +2 more sources