Results 11 to 20 of about 554,861 (311)

Overdiagnosis and overtreatment of breast cancer: Overdiagnosis in randomised controlled trials of breast cancer screening [PDF]

, 2005
Data from randomised controlled trials of mammographic screening can be used to determine the extent of any overdiagnosis, as soon as either a time equivalent to the lead-time has elapsed after the final screen, or the control arm has been offered ...
AB Miller, AB Miller, AB Miller, AB Miller, FE Alexander, FE Alexander, H Vainio, I Andersson, J Frisell, L Tabar, MF Yen, N Bjurstam, S Moss, S Moss, S Shapiro, S Shapiro, Sue Moss, SW Duffy, The Breast Screening Frequency Trial Group   +18 more
core   +3 more sources

Understanding randomised controlled trials [PDF]

Archives of Disease in Childhood, 2005
The hierarchy of evidence in assessing the effectiveness of interventions or treatments is explained, and the gold standard for evaluating the effectiveness of interventions, the randomised controlled trial, is discussed. Issues that need to be considered during the critical appraisal of randomised controlled trials, such as assessing the validity of ...
openaire   +2 more sources

Representation of people with comorbidity and multimorbidity in clinical trials of novel drug therapies: an individual-level participant data analysis

BMC Medicine, 2019
Background Clinicians are less likely to prescribe guideline-recommended treatments to people with multimorbidity than to people with a single condition. Doubts as to the applicability of clinical trials of drug treatments (the gold standard for evidence-
Peter Hanlon, Laurie Hannigan, Jesus Rodriguez-Perez, Colin Fischbacher, Nicky J. Welton, Sofia Dias, Frances S. Mair, Bruce Guthrie, Sarah Wild, David A. McAllister   +9 more
doaj   +1 more source

Determining external randomised pilot trial feasibility in preparation for a definitive trial: a web-based survey of corresponding authors of external pilot trial publications

Trials, 2023
Background External randomised pilot trials aim to determine whether a future definitive randomised controlled trial (RCT) should be conducted, and if so, how.
Katie Mellor, Susan J. Dutton, Sally Hopewell   +2 more
doaj   +1 more source

Measuring and reporting quality of life outcomes in clinical trials in cystic fibrosis: a critical review [PDF]

, 2005
Good quality clinical trials are essential to inform the best cystic fibrosis (CF) management and care, by determining and comparing the effectiveness of new and existing therapies and drug delivery systems.
Abbott, Janice, Hart, Anna
core   +2 more sources

Undertaking a randomised controlled trial in the police setting: methodological and practical challenges

Trials, 2017
Background There has been an increased drive towards Evidence Based Policing in recent years. Unlike in other public sector services, such as health and education, randomised controlled trials in the police setting are relatively rare.
Arabella Scantlebury, Catriona McDaid, Alison Booth, Caroline Fairhurst, Adwoa Parker, Rebecca Payne, Helen Reed, William J. Scott, David Torgerson, Catherine Hewitt   +9 more
doaj   +1 more source

Inclusion of progression criteria in external randomised pilot trials: a cross-sectional study of funding applications submitted to the NIHR Research for Patient Benefit Programme

Trials, 2022
Background External randomised pilot trials aim to assess whether a future definitive randomised controlled trial (RCT) is feasible. Pre-specified progression criteria help guide the interpretation of pilot trial findings to decide whether, and how, a ...
Katie Mellor, James Harwood, Jennie Hejdenberg, Ben Morgan, Susan J. Dutton, Sally Hopewell   +5 more
doaj   +1 more source

Evidence for risk of bias in cluster randomised trials: review of recent trials published in three general medical journals [PDF]

, 2003
Objective To examine the prevalence of a risk of bias associated with the design and conduct of cluster randomised controlled trials among a sample of recently published studies.
Puffer, S, Torgerson, D J, Watson, J
core   +2 more sources

Are randomised controlled trials positivist? Reviewing the social science and philosophy literature to assess positivist tendencies of trials of social interventions in public health and health services

Trials, 2018
Background We have previously proposed that trials of social interventions can be done within a “realist” research paradigm. Critics have countered that such trials are irredeemably positivist and asked us to explain our philosophical position.
Chris Bonell, Graham Moore, Emily Warren, Laurence Moore   +3 more
doaj   +1 more source

Cholera vaccine clinical trials: A cross-sectional analysis of clinical trials registries

Human Vaccines & Immunotherapeutics, 2023
Cholera has been one of the world’s biggest public health challenges for centuries. The presence of this disease brings into focus the social determinants of health in different parts of the world.
Lindi Mathebula, Thobile Malinga, Mammekwa Mokgoro, Duduzile Ndwandwe, Charles S. Wiysonge, Glenda Gray   +5 more
doaj   +1 more source