Results 71 to 80 of about 554,861 (311)

Recommendations for the analysis of individually randomised controlled trials with clustering in one arm – a case of continuous outcomes

BMC Medical Research Methodology, 2016
Background In an individually randomised controlled trial where the treatment is delivered by a health professional it seems likely that the effectiveness of the treatment, independent of any treatment effect, could depend on the skill, training or even ...
Laura Flight, Annabel Allison, Munyaradzi Dimairo, Ellen Lee, Laura Mandefield, Stephen J. Walters   +5 more
doaj   +1 more source

Checklist to assess Trustworthiness in RAndomised Controlled Trials (TRACT checklist): concept proposal and pilot

Research Integrity and Peer Review, 2023
Objectives To propose a checklist that can be used to assess trustworthiness of randomized controlled trials (RCTs). Design A screening tool was developed using the four-stage approach proposed by Moher et al.
Ben W. Mol, Shimona Lai, Ayesha Rahim, Esmée M. Bordewijk, Rui Wang, Rik van Eekelen, Lyle C. Gurrin, Jim G. Thornton, Madelon van Wely, Wentao Li   +9 more
doaj   +1 more source

Registry randomised trials: a methodological perspective

BMJ Open, 2023
Registry randomised clinical trials (RRCTs) have the potential to provide pragmatic answers to important clinical questions. RRCTs can be embedded into large population-based registries or smaller single site registries to provide timely answers at a ...
Christopher M Reid, Susannah Ahern, Ian Harris, Steven Y C Tong, Angela L Brennan, Dorota A Doherty, Carol Hodgson, Stephen McDonald, Jennifer Reilly, Jane Shrapnel, Charmaine S Tam, Leonie Wilcox, Anitha Balagurunathan, Belinda E Butcher   +13 more
doaj   +1 more source

Decision aids for randomised controlled trials : a qualitative exploration of stakeholders' views [PDF]

, 2014
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Campbell, Marion K, Gillies, Kate, Skea, Zoë C   +2 more
core   +1 more source

A Comparative Study of Cerebral Oxygenation During Exercise in Hemodialysis and Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Cognitive impairment and exercise intolerance are common in dialysis patients. Cerebral perfusion and oxygenation play a major role in both cognitive function and exercise execution; HD session per se aggravates cerebral ischemia in this population. This study aimed to compare cerebral oxygenation and perfusion at rest and in mild
Marieta P. Theodorakopoulou, Konstantina Dipla, Danai Faitatzidou, Fotini Iatridi, Areti Georgiou, Artemios Karagiannidis, Erasmia Sampani, Chrysostomos Dimitriadis, Aggelos Koutlas, Andreas Zafeiridis, Pantelis Sarafidis   +10 more
wiley   +1 more source

Corticosteroids for the common cold [PDF]

, 2015
BACKGROUND: The common cold is a frequent illness, which, although benign and self limiting, results in many consultations to primary care and considerable loss of school or work days. Current symptomatic treatments have limited benefit.
Del Mar, Chris B., Glasziou, Paul P., Hayward, Gail, Heneghan, Carl J., Perera, Rafael, Thompson, Matthew J.   +5 more
core   +1 more source

Understanding controlled trials: Why are randomised controlled trials important? [PDF]

BMJ, 1998
Randomised controlled trials are the most rigorous way of determining whether a cause-effect relation exists between treatment and outcome and for assessing the cost effectiveness of a treatment. They have several important features: Other study designs, including non-randomised controlled …
Sibbald, B., Roland, M.
openaire   +3 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease [PDF]

, 2015
Background: Globally, about five per cent of children are born with congenital or genetic disorders. The most common autosomal recessive conditions are thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease, with higher carrier rates in
Abbot, Alhamdan, Alswaidi, Alwan, American College of Obstetricians and Gynecologists, Angastiniotis, Angastiniotis, Angastiniotis, Anido, Bach, Barbarin, Bekker, Bekker, Bell, Bonham, Borry, Boulton, Bregnballe, Callanan, Cao, Castellani, Castellani, Cheuvront, Childs, Childs, Christie, Clayton, Czeizel, Davies, Donner, Dormandy, Dyson, Fanos, Fisher, Fowzan, Gharaibeh, Glasscoe, Hegwer, Henneman, Henneman, Henneman, Heyes, Higgins, Honnor, Jones, Kaback, Kenen, Lakeman, Lapham, Lau, Lena-Russo, Lew, Lewis, Locock, Loukopoulos, Massie, Mennie, Mitchell, Modell, Modell, Modell, Modell, Palomaki, Payne, Peters, Petersen, Poppelaars, Qureshi, Ratip, Rose P. Humm, Rowley, Rowley, Samavat, Shapira, Smith, Tambor, Teeuw, Telfer, Ukoumunne, Watson, Watson, Watson, Weatherall, Whitten, Wilkie, Wille, Wilson, Yusuf, Zeesman, Zeuner   +89 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source