Results 81 to 90 of about 554,861 (311)

The effect of the APOE4 genotype on physiological and cognitive health in randomised controlled trials with an exercise intervention: a systematic review and meta-analysis

Trials
Background Alzheimer’s disease is caused by modifiable and non-modifiable risk factors. Randomised controlled trials have investigated whether the strongest genetic risk factor for Alzheimer’s disease, APOE4, impacts the effectiveness of exercise on ...
Felicity S. E. Spencer, Richard J. Elsworthy, Leigh Breen, Jon R. B. Bishop, Connor Dunleavy, Sarah Aldred   +5 more
doaj   +1 more source

Oral rehydration versus intravenous therapy for treating dehydration due to gastroenteritis in children: a meta-analysis of randomised controlled trials [PDF]

, 2004
BACKGROUND: Despite treatment recommendations from various organizations, oral rehydration therapy (ORT) continues to be underused, particularly by physicians in high-income countries.
A Mackenzie, A Mackenzie, A Oxman, AL Nager, AM Tamer, American Academy of Pediatrics, AR Jadad, C Duggan, CB Begg, Cochrane Library, Database of Abstracts of Reviews of Effectiveness, D Gremse, Don McConnell, EC Reis, G Jones, GA Colditz, GP Conners, J Sharifi, JD Snyder, JJ Deeks, JS Garland, K Armon, Kelly Russell, KF Schulz, Lisa Hartling, LV Hedges, M Egger, M el-Mougi, M Santosham, M Santosham, M Singh, Martin M De Pumarejo, N Gavin, Natasha Wiebe, O Fontaine, P Ozuah, R Listernick, RM Issenman, S Duval, S Hahn, SR Gonzalez-Adriano, Steven Bellemare, T Vesikari, Terry P Klassen, TP Klassen, William R Craig, World Health Organization, World Health Organization, YC Atherly-John   +47 more
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomised controlled trial

Journal of Nutritional Science, 2015
Accumulating evidence suggests an association between gut microbiota and the development of obesity, raising the possibility of probiotic administration as a therapeutic approach.
Jun-ichi Minami, Shizuki Kondo, Naotake Yanagisawa, Toshitaka Odamaki, Jin-zhong Xiao, Fumiaki Abe, Shigeru Nakajima, Yukie Hamamoto, Sanae Saitoh, Taeko Shimoda   +9 more
doaj   +1 more source

Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials [PDF]

, 2001
BACKGROUND: Hormone replacement therapy (HRT) is often seen as the treatment of choice for preventing fractures in women. We undertook a recent meta-analysis of randomised trials which suggested that HRT reduced non-vertebral fractures by 30%.
Bell-Syer, Sally E.M., Torgerson, David J.   +1 more
core   +3 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Non-strategic ignorance: Considering the potential for a paradigm shift in evidence-based mental health [PDF]

, 2018
Randomised controlled trials form a central building block within the prevailing evidence-based mental health paradigm. Both methodology and paradigm have been widely problematised since their emergence in the mid-late twentieth century.
Cochrane A, Department of Health, Department of Health, Department of Health, Department of Health, Felicitas Rost, Kleinman A, Kuhn T, Latour B, Maxine Dennis, Richardson PH, Sukhjit Sidhu, Susan McPherson   +12 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Mammographic screening: evidence from randomised controlled trials [PDF]

, 2003
BACKGROUND: All randomised breast cancer screening trials have shown a reduction in breast cancer mortality in the 'invited for mammography' screening arm compared with the 'control arm' for women aged 50 years and older at ...
Koning, H.J. (Harry) de
core   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source