Results 111 to 120 of about 521,586 (313)

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Exploiting correlation in the construction of D-optimal response surface designs. [PDF]

Cost considerations and difficulties in performing completely randomized experiments often dictate the necessity to run response surface experiments in a bi-randomization format.
Goos, Peter, Vandebroek, Martina
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Study enrollment and randomization.

, 2016
Study enrollment and randomization.
Mhairi Maskew (138509), Celeste Sauls (1888846), Cynthia Nyoni (2736340), Constance Mongwenyana (361724), Ian Sanne (170641), Sydney Rosen (213204), Dorah Bokaba (2736349), Julia Rohr (2736346), Matthew P. Fox (213205), Lawrence Long (320846), Given Malete (2736343)   +10 more
core   +2 more sources

Valid randomization.

, 1987
Sufficient combinatorial conditions for weak and strong validity of randomization are well known for some common classes of designs with single error strata.
Bailey, Rosemary Anne, Rowley, C. A., Bailey, R. A., Bailey, Rosemary Anne; id_orcid   +3 more
core  

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Restricted randomization

, 1983
A method of restricted randomization is given suitable for any block structure in which the number of levels of each block factor is a prime power. Under the assumption that all blocks are linear, certain patterns are designated undesirable, and initial ...
Bailey, Rosemary Anne, Bailey, R. A., Bailey, Rosemary Anne; id_orcid   +2 more
core  

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Optimal allocation of sample size for randomization-based inference from 2K factorial designs

Journal of Causal Inference
Optimizing the allocation of units into treatment groups can help researchers improve the precision of causal estimators and decrease costs when running factorial experiments.
Ravichandran Arun, Pashley Nicole E., Libgober Brian, Dasgupta Tirthankar   +3 more
doaj   +1 more source