Results 121 to 130 of about 1,182,141 (298)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Retardation of Myopia by Multifocal Soft Contact Lens and Orthokeratology: A 1-Year Randomized Clinical Trial

open access: hybrid, 2022
Jianxia Fang   +7 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Mendelian Randomization Analysis of the Relationship Between Immune-Related Diseases and Alzheimer’s Disease

open access: yesJournal of Multidisciplinary Healthcare
Dong-Hong Huang,1,* Yue-ling Zhang,1,* Sheng-Liang Shi,1 Tian-Jia Liang,2 Jun-jian Chen,3 Guo-Qiao Li,4 Zhao-De Chen2 1Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University, Guangxi, 530000, People’s ...
Huang DH   +6 more
doaj  

Preemptive effects of etoricoxib, acetaminophen, nimesulide, and ibuprofen on postoperative pain management after single‐implant surgery: A randomized clinical trial [PDF]

open access: bronze, 2023
Gustavo Henrique Mattos Pereira   +4 more
openalex   +1 more source

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