Results 181 to 190 of about 682,500 (222)

Exploratory Mendelian randomization analysis: The genetic susceptibility of CT examination preference and the risk of hypertrophic cardiomyopathy. [PDF]

Medicine (Baltimore)
Dong Q, Han B, Wang N.
europepmc   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Assessing allocation bias in stratified clinical trials with multi-component endpoints evaluated using the stratified Wei-Lachin test. [PDF]

PLoS One
Schoenen S, Heussen N, Hilgers RD.
europepmc   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Randomized Controlled Trial of the Meaning-Making Intervention (MMi) in Patients Newly Diagnosed With Advanced Cancer: Full Trial. [PDF]

Psychooncology
Henry M, Cohen SR, Heyland DK, Platt R, Zhang X, Gotlieb W, Lau S, Vasilevsky CA, Hier M, Sadeghi N, Sultanem K, Batist G, Costa M, Bolster-Foucault C, Wang CS, Agulnik J.   +15 more
europepmc   +1 more source

Exploring the impact of childhood obesity on sarcopenia-related traits: A 2-way Mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Zhao M, Guo T, Liu C.
europepmc   +1 more source

Deciphering casual association between brain structure and liver cirrhosis: Insights from Mendelian randomization. [PDF]

Medicine (Baltimore)
Xiong X, Yang G, Yao Y, Lin C.
europepmc   +1 more source

Association of endometriosis with hematuria markers: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Huang SP, Zhang ZC, Li J, Li LY, Ding WJ, Xie CY, Zhang YT, Li WH.   +7 more
europepmc   +1 more source

Immune Microenvironment Dynamics and Therapeutic Targets in GIST Revealed by Multi-Omics and Functional Validation. [PDF]

J Cell Mol Med
Li X, Xiang J, Chang Z, Tang Q.
europepmc   +1 more source