Results 161 to 170 of about 521,586 (313)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
A Randomized Q-OR Krylov Subspace Method for Solving Nonsymmetric Linear Systems
MathematicsThe most popular iterative methods for solving nonsymmetric linear systems are Krylov methods. Recently, an optimal Quasi-ORthogonal (Q-OR) method was introduced, which yields the same residual norms as the Generalized Minimum Residual (GMRES) method ...
Gérard Meurant
doaj +1 more source
Summary of randomization test.
, 2016 Summary of randomization test.
Camel Tanougast (2270119) +5 more
core +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Cow characteristics after randomization.
, 2019 Cow characteristics after randomization.
Rodolfo Santos Rossi (6125957) +6 more
core +1 more source
ACM Transactions on Computational LogicArranging the bits of a random string or real into \( k \) columns of a 2D array or higher dimensional structure is typically accompanied with loss in the Kolmogorov complexity of the columns, which depends on
George Barmpalias, Xiaoyan Zhang
openaire +3 more sources
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Journal of Multidisciplinary HealthcareDong-Hong Huang,1,* Yue-ling Zhang,1,* Sheng-Liang Shi,1 Tian-Jia Liang,2 Jun-jian Chen,3 Guo-Qiao Li,4 Zhao-De Chen2 1Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University, Guangxi, 530000, People’s ...
Huang DH +6 more
doaj