Results 151 to 160 of about 521,586 (313)

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Deterministic versus Stochastic Mechanisms in Principal–Agent Models [PDF]

This paper shows that, contrary to what is generally believed, decreasing concavity of the agent’s utility function with respect to the screening variable is not sufficient to ensure that stochastic mechanisms are suboptimal.
Strausz, Roland
core   +2 more sources

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Treating patients with acute myeloid leukemias (AML) according to the protocol of the AML-01.10 Russian multicenter randomized trial: the Coordinating Center's results

Терапевтический архив, 2014
AIM. To make a randomized comparison of 2 consolidation treatment options (two patient groups): 2 cycles of cytarabine in average (1g/m2 in Group 2) and standard (100 mg/m2 in Group 1) doses in combination with idarubicin (8-12 mg/m2) and mitoxantrone ...
E N Parovichnikova, V V Troitskaia, G A Kliasova, L A Kuz'mina, A N Sokolov, E V Paramonova, G M Galstian, S A Kessel'man, M Iu Drokov, V A Vasil'eva, T N Obukhova, S M Kulikov, V G Savchenko   +12 more
doaj  

A Lightweight Browser-Based Tool for Collaborative and Blinded Image Analysis

Journal of Imaging
Collaborative manual image analysis by multiple experts in different locations is an essential workflow in biomedical science. However, sharing the images and writing down results by hand or merging results from separate spreadsheets can be error-prone ...
Philipp Schippers, Gundula Rösch, Rebecca Sohn, Matthias Holzapfel, Marius Junker, Anna E. Rapp, Zsuzsa Jenei-Lanzl, Philipp Drees, Frank Zaucke, Andrea Meurer   +9 more
doaj   +1 more source

Patients enrollment and randomization.

, 2018
Patients enrollment and randomization.
Márcio Manozzo Boniatti (5186969), Viviane Corrêa Boniatti (5680082), Wagner Luiz Nedel (5680091), Leonardo da Silva Marques (5680094), Cláudia Pellizzer Dal’ Pizzol (5680103), Patrícia Klarmann Ziegelmann (5680106), Moreno Calcagnotto dos Santos (5680097), Sílvia Regina Rios Vieira (5680109), Crislene Zigiotto (5680085), José Augusto Santos Pellegrini (5680079), Clarissa Balbão de Almeida (5680100), Marina Verçoza Viana (5680088)   +11 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Randomization Example

Data for a simple randomization example.
Martins, Henrique
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Genetic Markers as Instrumental Variables [PDF]

The use of genetic markers as instrumental variables (IV) is receiving increasing attention from epidemiologists, economists, statisticians and social scientists.
Frank Windmeijer, Carol Propper, Stephanie von Hinke Kessler Scholder, George Davey Smith, Debbie A. Lawlor   +4 more
core