Results 191 to 200 of about 521,586 (313)

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Comments to "Efficacy of Electroacupuncture for Chronic Pelvic Pain: A Randomized, Single-Blind, Sham-Controlled Trial" [Letter]. [PDF]

J Pain Res
Zhao Y, Chen S.
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Stroke and brain white/gray matter alterations: A Mendelian randomization investigation. [PDF]

Medicine (Baltimore)
Wu X, Yang L, Xu W, Guan H.
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

The Effect of Behavioral Interventions That Include Goal Setting on Pain, Disability, and Physical Activity in People With Chronic Musculoskeletal Pain: A Systematic Review and Meta-Analysis. [PDF]

Clin J Pain
Natoli AR, Gibbs MT, Mishra I, Devonshire J, O'Brien-Smith J, McAuley JH, Cashin AG, Jones MD, Jones MD.   +8 more
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Coated or chewable aspirin and a hybrid air pollution mitigation strategy in patients with atherosclerotic disease: rationale and design of the COATED-AIR randomized trial. [PDF]

Eur Heart J Cardiovasc Pharmacother
Bikdeli B, Talasaz AH, Bakhshandeh H, Hassanvand MS, Kakavand H, Jamalkhani S, Rashedi S, Tayyebi S, Babaei M, Kohansal E, Ghoshouni H, Mohtasham Kia Y, Nikkhoo M, Mohebbi B, Aghakouchakzadeh M, Alipour-Parsa S, Elahifar A, Khalilipur E, Omidvar R, Mehrpooya M, Sezavar SH, Jimenez D, Jara Palomares L, Mazloomzadeh S, Hadavand N, Ansari Dogaheh M, Maleki M, Noohi F, Ortega-Paz L, Raikhelkar JK, Steg PG, Lopes RD, De Caterina R, Shishehbor MH, Laine L, Angiolillo DJ, Rajagopalan S, Kirtane AJ, Piazza G, Lip GYH, Mehran R, Krumholz HM, Ridker PM, Sadeghipour P, COATED-AIR Investigators.   +44 more
europepmc   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source