Results 51 to 60 of about 9,831,579 (305)
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Probability-boosting technique for combinatorial optimization [PDF]
PeerJ Computer ScienceIn many combinatorial optimization problems we want a particular set of k out of n items with some certain properties (or constraints). These properties may involve the k items.
Sanpawat Kantabutra
doaj +2 more sources
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
A randomized approximate nearest neighbors algorithm [PDF]
Applied and Computational Harmonic Analysis, 2011 We present a randomized algorithm for the approximate nearest neighbor problem in d -dimensional Euclidean space. Given N points { x j } in , the ...
Peter Wilcox, Jones +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Randomized algorithms for total least squares problems
Numerical Linear Algebra with Applications, 2018 Motivated by the recently popular probabilistic methods for low‐rank approximations and randomized algorithms for the least squares problems, we develop randomized algorithms for the total least squares problem with a single right‐hand side.
Pengpeng Xie, Hua Xiang, Yimin Wei
semanticscholar +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Randomized Parameterized Algorithms for the Kidney Exchange Problem
Algorithms, 2019 In order to increase the potential kidney transplants between patients and their incompatible donors, kidney exchange programs have been created in many countries.
Mugang Lin +3 more
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
AlgorithmsInteger linear programs (ILPs) and mixed integer programs (MIPs) often have multiple distinct optimal solutions, yet the widely used Gurobi optimization solver returns certain solutions at disproportionately high frequencies.
Noah Schulhof +4 more
doaj +1 more source