Results 71 to 80 of about 125,297 (309)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Finding Multiple Optimal Solutions to an Integer Linear Program by Random Perturbations of Its Objective Function

Algorithms
Integer linear programs (ILPs) and mixed integer programs (MIPs) often have multiple distinct optimal solutions, yet the widely used Gurobi optimization solver returns certain solutions at disproportionately high frequencies.
Noah Schulhof, Pattara Sukprasert, Eytan Ruppin, Samir Khuller, Alejandro A. Schäffer   +4 more
doaj   +1 more source

Model checking randomized distributed algorithms

, 2020
International audienceRandomization is a powerful paradigm to solve hard problems, especially in distributed computing. Proving the correctness, and assessing the performances, of randomized distributed algorithms, is a very challenging research ...
Bertrand, Nathalie
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Algorithms with greedy heuristic procedures for mixture probability distribution separation [PDF]

Yugoslav Journal of Operations Research, 2019
For clustering problems based on the model of mixture probability distribution separation, we propose new Variable Neighbourhood Search algorithms (VNS) and evolutionary genetic algorithms (GA) with greedy agglomerative heuristic procedures and compare ...
Kazakovtsev Lev, Stashkov Dmitry, Gudyma Mikhail, Kazakovtsev Vladimir   +3 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Randomized Estimation for Low-Light Imaging With Unknown-but-Bounded Noise

IEEE Access
This paper addresses parameter estimation in low-light imaging when the number of observations is limited and the dominant uncertainty is unknown-but-bounded dark noise.
Konstantin Amelin, Victoria Erofeeva, Oleg Granichin, Irina Len   +3 more
doaj   +1 more source

Non-Algorithmic Theory of Randomness [PDF]

, 2020
This paper proposes an alternative language for expressing results of the algorithmic theory of randomness. The language is more precise in that it does not involve unspecified additive or multiplicative constants, making mathematical results, in principle, applicable in practice.
openaire   +2 more sources

Approximation algorithms for hard variants of the stable marriage and hospitals/residents problems [PDF]

, 2007
When ties and incomplete preference lists are permitted in the Stable Marriage and Hospitals/Residents problems, stable matchings can have different sizes.
Irving, R.W., David F. Manlove, Robert W. Irving, Manlove, D.F.   +3 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source