Results 61 to 70 of about 125,297 (309)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
A randomized maximum-flow algorithm [PDF]
30th Annual Symposium on Foundations of Computer Science, 1989 Summary: A randomized algorithm for computing a maximum flow is presented. For an \(n\)-vertex \(m\)-edge network, the running time is \(O(nm + n^2 (\log n)^2)\) with probability at least \(1 - 2^{- \sqrt {nm}}\). The algorithm is always correct, and in the worst case runs in \(O(nm \log n)\) time.
Cheriyan, J., Hagerup, T.
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A Monad for Randomized Algorithms
Electronic Notes in Theoretical Computer Science, 2016 AbstractIn this paper, we introduce a monad of random choice for domains that does not suffer from the main two drawbacks of the probabilistic powerdomain. It is not known whether any Cartesian closed category of domains is closed under the probabilistic powerdomain, but the Cartesian closed category BCD is closed under this monad of random choice ...
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
An accelerated randomized Kaczmarz algorithm [PDF]
Mathematics of Computation, 2015 The randomized Kaczmarz ( R K \rm {RK} )
Ji Liu 0002, Stephen J. Wright 0001
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, 2003 In this paper we present two novel generic schemes for approximation algorithms for optimization to partial k-trees. Our first scheme yields deterministic polynomialtime algorithms achieving typically an approximation factor of k/ log n, where k
Chlebikova, Janka +14 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Do Randomized Algorithms Improve the Efficiency of Minimal Learning Machine?
Machine Learning and Knowledge Extraction, 2020 Minimal Learning Machine (MLM) is a recently popularized supervised learning method, which is composed of distance-regression and multilateration steps. The computational complexity of MLM is dominated by the solution of an ordinary least-squares problem.
Joakim Linja +3 more
doaj +1 more source