Randomized controlled trial of transfer factor in stage II malignant melanoma [PDF]
Ronald M. Bukowski+3 more
openalex +1 more source
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald+18 more
wiley +1 more source
Does Prophylacitc Medication Reduce Intrauterin Device (IUD) Insertion Pain in Women of Childbearing Age? [PDF]
OBJECTIVE: The objective of this selective EBM review is to determine whether or not prophylactic medication reduces intrauterine device (IUD) insertion pain in women of childbearing age.
Deshaies, Mariel M.
core +1 more source
Post-Thyroidectomy Hypocalcemia and Effects of Pre-Operative Calcium Supplements on its Incidence
Objective: To determine the effects of pre-operative Calcium supplements on post-total thyroidectomy hypocalcemia. Study Design: Randomized Control Trial (IRCT Id20231016059739N1).
Erisha Komal+5 more
doaj +1 more source
Understanding and measuring mechanical signals in the tumor stroma
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz+3 more
wiley +1 more source
Effectiveness of foot orthosis in patients with rheumatoid arthritis related to quality of life and pain. A systematic review and meta-analysis [PDF]
Foot pain and deformity is almost ubiquitous in RA and results in considerable physical and psychosocial impairment. Epidemiological studies consistently suggest a 90% prevalence of foot pain despite advances in pharmacological therapy.
García-Mayor, Silvia+3 more
core
Somchai Amornyotin, Wiyada Chalayonnawin, Siriporn KongphlayDepartment of Anesthesiology and Siriraj GI Endoscopy Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandIntroduction: Parecoxib is occasionally used for ...
Amornyotin S+2 more
doaj
Doubly robust omnibus sensitivity analysis of externally controlled trials with intercurrent events [PDF]
Externally controlled trials are crucial in clinical development when randomized controlled trials are unethical or impractical. These trials consist of a full treatment arm with the experimental treatment and a full external control arm. However, they present significant challenges in learning the treatment effect due to the lack of randomization and ...
arxiv
Chronic adjunctive trimazosin vasodilator therapy in heart failure: A six month double-blind placebo controlled randomized trial [PDF]
Philip C. Kirlin+5 more
openalex +1 more source
Hydrogen sulfide repairs testicular damage induced by heat stress in rats
Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo+6 more
wiley +1 more source