Results 111 to 120 of about 346,597 (387)

“It’s trying to manage the work” : A qualitative evaluation of recruitment processes within a UK multi-centre trial [PDF]

, 2017
Acknowledgments The authors would like to thank all interviewees who agreed to take part in this study. The authors would like to thank the TISU Trial Group for their support with this project. In particular, the authors would like to thank Sarah Cameron
Gillies, Katie, Skea, Zoe Christina, Treweek, Shaun   +2 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Effect of consuming food cooked in iron pots and behavior change communication on iron status in non-pregnant, non-lactating women: protocol for randomized controlled trial

Trials
Background Iron-deficiency anemia (IDA) remains a significant public health concern, particularly among women of reproductive age in developing countries.
Umesh Kawalkar, Shital Telrandhe, Mahalaqua Nazli Khatib, Shilpa Gaidhane, Zahiruddin Quazi Syed, Amar Mankar, Abhay Gaidhane   +6 more
doaj   +1 more source

Impact of Group vs. Individual Prenatal Care Provision on Women’s Knowledge of Pregnancy-Related Topics: An Open, Controlled, Semi-Randomized Community Trial [PDF]

, 2022
Ronit Ratzon, Arnon D. Cohen, Amnon Hadar, Miron Froimovici, Natalya Bilenko   +4 more
openalex   +1 more source

The effect of goal-directed therapy on mortality in patients with sepsis - earlier is better: a meta-analysis of randomized controlled trials

Critical Care, 2014
IntroductionThe Surviving Sepsis Campaign guidelines recommend goal-directed therapy (GDT) for the early resuscitation of patients with sepsis. However, the findings of the ProCESS (Protocolized Care for Early Septic Shock) trial showed no benefit from ...
Wan-Jie Gu, Fei Wang, J. Bakker, Lu Tang, Jing-chen Liu   +4 more
semanticscholar   +1 more source

Challenges in evaluating surgical innovation [PDF]

, 2009
Research on surgical interventions is associated with several methodological and practical challenges of which few, if any, apply only to surgery. However, surgical evaluation is especially demanding because many of these challenges coincide.
Blazeby, Jane M, Boutron, Isabelle, Clavein, Pierre-Alain, Cook, Jonathan Alistair, Ergina, Patrick L, Reeves, Barnaby C, Seiler, Christoph M   +6 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Venous thromboembolism prevention protocol for adapting prophylaxis recommendations to the potential risk post total knee replacement: a randomized controlled trial

Pharmacy Practice, 2020
Background: Total knee replacement (TKR) is a major orthopedic surgery that is considered high risk for the development of venous thromboembolism (VTE).
Mariam A. Alameri , Syed A. Syed Sulaiman , Abdullah M. Ashour , Ma’ad F. Al-Saati   +3 more
doaj   +1 more source

Exploratory randomized controlled trial evaluating the impact of a waiting list control design [PDF]

, 2016
BACKGROUND Employing waiting list control designs in psychological and behavioral intervention research may artificially inflate intervention effect estimates.
Cunningham, John A, Kypri, Kypros, McCambridge, Jim   +2 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source