Results 121 to 130 of about 1,683,394 (322)

Efficacy and Effectiveness of Exercise on Tender Points in Adults with Fibromyalgia: A Meta-Analysis of Randomized Controlled Trials

Arthritis, 2011
Fibromyalgia is a major public health problem affecting an estimated 200 to 400 million people worldwide. The purpose of this study was to use the meta-analytic approach to determine the efficacy and effectiveness of randomized controlled exercise ...
G. Kelley, K. Kelley, Dina L. Jones
semanticscholar   +1 more source

Is intermittent short-course anti-TB regimen as efficient and safe as daily anti-TB regimen for treating childhood TB?

Journal of Family Medicine and Primary Care, 2015
Childhood tuberculosis (TB) is a common clinical condition in low- and middle-income nations like India where TB is endemic. Different guidelines vary in the recommendations on treatment regimes for childhood TB. Apart from clinical outcomes the decision
Soumyadeep Bhaumik
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial

Anesthesiology, 2019
What We Already Know about This Topic Preclinical and clinical studies suggest that lidocaine might be neuroprotective, which could benefit surgical patients at risk of neurologic compromise What This Article Tells Us That Is New This multicenter trial ...
Rebecca Y. Klinger, M. Cooter, Tiffany L. Bisanar, N. Terrando, M. Berger, M. Podgoreanu, M. Stafford-Smith, M. Newman, J. Mathew, J. Blumenthal, Jörn Karhausen, M. Kertai, V. Krishnamoorthy, Yi-Ju Li, M. Swaminathan, D. Warner, B. Funk, R. Brassard, Y. Toulgoat-Dubois, P. Waweru, M. Babyak, Jeffrey N. Browndyke, K. Welsh-Bohmer, M. Sketch, E. Bennett, C. Graffagnino, D. Laskowitz, W. Strittmatter, Kevin Collins, G. Smigla, Ian R. Shearer, T. D’amico, M. Daneshmand, J. Gaca, D. Glower, J. Haney, D. Harpole, M. G. Hartwig, G. Hughes, J. Klapper, Shu-sen Lin, A. Lodge, C. Milano, Ryan P Plichta, Jacob N. Schroeder, Peter K. Smith, B. Tong   +46 more
semanticscholar   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Impact of Group vs. Individual Prenatal Care Provision on Women’s Knowledge of Pregnancy-Related Topics: An Open, Controlled, Semi-Randomized Community Trial [PDF]

, 2022
Ronit Ratzon, Arnon D. Cohen, Amnon Hadar, Miron Froimovici, Natalya Bilenko   +4 more
openalex   +1 more source

Anti-PD-(L)1 for KRAS-mutant advanced non-small–cell lung cancers: a meta-analysis of randomized–controlled trials

Cancer Immunology and Immunotherapy, 2021
T. Landre, G. Justeau, J. Assié, K. Chouahnia, C. Davoine, C. Taleb, C. Chouaïd, B. Duchemann   +7 more
semanticscholar   +1 more source

Blood Purification and Mortality in Sepsis and Septic Shock: A Systematic Review and Meta-analysis of Randomized Trials.

Anesthesiology, 2019
WHAT WE ALREADY KNOW ABOUT THIS TOPIC Among patients with sepsis or septic shock, a variety of extracorporeal blood purification techniques are availableIndividual existing trials evaluating these options are underpowered to provide clear evidence WHAT ...
A. Putzu, R. Schorer, J. Lopez-Delgado, T. Cassina, G. Landoni   +4 more
semanticscholar   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Evaluation of the impact of “speak out” and “human libraries” educational methodologies on nursing students' attitudes toward immigration

Frontiers in Public Health
IntroductionMeasuring and understanding attitudes toward migrants is crucial in Health Sciences professionals. Nursing students, as future professionals in the healthcare system, must be comprehensively trained and prepared from the undergraduate level ...
Vicente Gea-Caballero, Ana Pellín-Carcelén, José Luís Piera-Gomar, María Isabel Mármol-López, Iván Santolalla-Arnedo, Clara Isabel Tejada Garrido, Amaya Burgos-Esteban, María Rasal Sánchez, Amparo Rasal Sánchez, María Inmaculada Carboneres-Tafaner, Raúl Juárez-Vela   +10 more
doaj   +1 more source