Results 71 to 80 of about 176,739 (297)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Methodological and statistical topics in randomized controlled clinical trials [PDF]

, 1999
Escosteguy Claudia Caminha
openalex   +3 more sources

Immunosuppressive serum levels in allogeneic hematopoietic stem cell transplantation: pharmaceutical care contribution

Pharmacy Practice, 2016
Background: Cyclosporine and tacrolimus are limited by a narrow therapeutic window. Maintaining immunosuppressive drugs at desired levels may be difficult.
Corrêa PM, Zuckermann J, Fischer GB, Castro MS.   +3 more
doaj   +1 more source

Effect of Topical Chamomile Oil (Matricaria chamomile L.) as a Supplementary Method on Colic Symptoms in Infants: A Randomized Placebo-controlled Clinical Trial

Iranian Journal of Neonatology, 2019
Background: The aim of this study was to evaluate the efficacy of the topical use of chamomile oil as a complementary method in the improvement of infantile colic symptoms. Methods: This randomized controlled trial was carried out on 74 infants with colic at Sabzevar University of Medical Sciences in Sabzevar, Iran.
Salehipoor, Hassan, Afzali, Behzad, Akrami, Rahim, Ghorat, Fereshteh, Niktabe, Zahra, Sahebkar, Mohammad   +5 more
openaire   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Topical pravibismane as adjunctive therapy for moderate or severe diabetic foot infections: A phase 1b randomized, multicenter, double‐blind, placebo‐controlled trial

International Wound Journal
AbstractThis Phase 1b study was designed to evaluate the safety and efficacy of pravibismane, a novel broad‐spectrum topical anti‐infective, in managing moderate or severe chronic diabetic foot ulcer (DFU) infections. This randomized, double‐blind, placebo‐controlled, multicenter study consisted of 39 individuals undergoing pravibismane treatment and ...
Lipsky, Benjamin A., Kim, Paul J., Murphy, Brian, McKernan, Patricia A., Armstrong, David G., Baker, Brett H. J.   +5 more
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Evaluation of the impact of “speak out” and “human libraries” educational methodologies on nursing students' attitudes toward immigration

Frontiers in Public Health
IntroductionMeasuring and understanding attitudes toward migrants is crucial in Health Sciences professionals. Nursing students, as future professionals in the healthcare system, must be comprehensively trained and prepared from the undergraduate level ...
Vicente Gea-Caballero, Ana Pellín-Carcelén, José Luís Piera-Gomar, María Isabel Mármol-López, Iván Santolalla-Arnedo, Clara Isabel Tejada Garrido, Amaya Burgos-Esteban, María Rasal Sánchez, Amparo Rasal Sánchez, María Inmaculada Carboneres-Tafaner, Raúl Juárez-Vela   +10 more
doaj   +1 more source

Evaluation of a communication skills training to facilitate addressing palliative care related topics in advanced cancer patients: study protocol of a multicenter randomized controlled trial (PALLI-KOM) [PDF]

, 2020
Nele Harnischfeger, Hilke M. Rath, Anneke Ullrich, Bernd Alt‐Epping, Anne Letsch, Peter Thuss‐Patience, Carsten Bokemeyer, Karin Oechsle, Corinna Bergelt   +8 more
openalex   +1 more source