Results 61 to 70 of about 188,812 (316)

Study-based registers of randomized controlled trials: Starting a systematic review with data extraction or meta-analysis [PDF]

BioImpacts, 2017
Introduction: Despite years of use of study-based registers for storing reports of randomized controlled trials (RCTs), the methodology used in developing such registers/databases has not been documented.
Farhad Shokraneh, Clive Elliott Adams
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Efficacy and safety of 0.5% colchicine cream versus 5% 5-fluorouracil cream in the treatment of cutaneous field cancerization: a randomized clinical trial [PDF]

Anais Brasileiros de Dermatologia
Background 5-Fluorouracil (5-FU) is a first-line drug to treat cutaneous field cancerization (CFC). There are few clinical trials with topical colchicine (COL).
Amanda Soares Teixeira, Ivanka Miranda de Castro Martins, Anna Carolina Miola, Hélio Amante Miot   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Importance of achieving the composite endpoints in diabetes

Indian Journal of Endocrinology and Metabolism, 2013
Well-conducted randomized controlled trials are instrumental in providing vital data on safety and efficacy of new molecules under consideration for approval. However acquiring such data involves huge cost and focused scientific endeavor.
Ambika Gopalakrishnan Unnikrishnan, Arpandev Bhattacharyya, Manash Pratim Baruah, Binayak Sinha, Mala Dharmalingam, Paturi V Rao   +5 more
doaj   +1 more source

A Randomized Controlled Trial on the Hemostasis of Femoral Artery Using Topical Hemostatic Agent [PDF]

Clinical and Applied Thrombosis/Hemostasis, 2012
Objective: Evaluation of the effect of using a topical hemostatic agent named “ChitoHem ® ” on different factors on patients undergoing diagnostic coronary angiography. Methods: The present blind, randomized, controlled study included 124 patients randomly divided into 2 groups.
Soheila S, Kordestani, Fereidoon, Noohi, Hossein, Azarnik, Hossein, Basiri, M J, Hashemi, S, Abdi, A, Mohebi, M, Madani, Farzaneh, Nayebhabib   +8 more
openaire   +2 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Final results of a phase I/II pilot study of capecitabine with or without vinorelbine after sequential dose-dense epirubicin and paclitaxel in high-risk early breast cancer

, 2010
Background: The integration of the non-cross-resistant chemotherapeutic agents capecitabine and vinorelbine into an intensified dose-dense sequential anthracycline- and taxane-containing regimen in high-risk early breast cancer (EBC) could improve ...
Schmidt Marcus, Hinke Axel, Volkmar Müller, Heilmann Volker, Borowicz, Henryk, Lehnert, Antje, Volker Heilmann, Müller, Volkmar, Axel Hinke, Jackisch, Christian, Möbus, Volker, Christoph Thomssen, Marcus Schmidt, Thomssen, Christoph, Jackisch Christian, Antje Lehnert, Lehnert Antje, Christian Jackisch, Schmidt, Marcus, Glados, Manfred, Heilmann, Volker, Manfred Glados, Volker Möbus, Thomssen Christoph, Henryk Borowicz, Borowicz Henryk, Müller Volkmar, Möbus Volker, Hinke, Axel, Glados Manfred   +29 more
core   +1 more source

Phototherapy with Topical Minoxidil in Vitiligo: A Randomized Control Trial

Indian Dermatology Online Journal
Abstract Background: Phototherapy is the most commonly used treatment for vitiligo, with initial pigment appearing at the perifollicular site, eventually coalescing into uniform pigmentation due to melanocyte migration from hair follicles.
Sejal Bajoria, Chakravarthi R. Srinivas, Nithya Satish, Riya Sukhija, Kriti Jain, Garima Manocha, Laxman Besra   +6 more
openaire   +2 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source