Results 71 to 80 of about 57,506,680 (308)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional Relaxation and Guided Imagery as Complementary Therapy in Asthma: A Randomized Controlled Clinical Trial [PDF]

, 2009
Background: Asthma is a frequently disabling and almost invariably distressing disease that has a high overall prevalence. Although relaxation techniques and hypnotherapeutic interventions have proven their effectiveness in numerous trials, relaxation ...
N. Sauer, F. Röhricht, D. Nowak, Loew, T., C. Lahmann, T. Schuster, Sauer, N., Nowak, Dennis, K. Tritt, M. Nickel, T. Loew, Ronel, J., M. Noll-Hussong, Schuster, T., Tritt, K., Noll-Hussong, M., J. Ronel, Lahmann, Claas, Lahmann, C., Röhricht, F., Nickel, M., Nowak, D., Lahmann, C.;Nickel, M.;Schuster, T.;Sauer, N.;Ronel, J.;Noll-Hussong, M.;Tritt, K.;Nowak, D.;Röhricht, F.;Loew, T., Lahmann, C;Nickel, M;Schuster, T;Sauer, N;Ronel, J;Noll-Hussong, M;Tritt, K;Nowak, D;Rohricht, F;Loew, T   +23 more
core   +1 more source

Study-based registers of randomized controlled trials: Starting a systematic review with data extraction or meta-analysis [PDF]

BioImpacts, 2017
Introduction: Despite years of use of study-based registers for storing reports of randomized controlled trials (RCTs), the methodology used in developing such registers/databases has not been documented.
Farhad Shokraneh, Clive Elliott Adams
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Evaluation of the effectiveness and cost-effectiveness of Families for Health V2 for the treatment of childhood obesity : study protocol for a randomized controlled trial [PDF]

, 2013
Background: Effective programs to help children manage their weight are required. Families for Health focuses on a parenting approach, designed to help parents develop their parenting skills to support lifestyle change within the family.
Petrou, Stavros, Reddington, Kate, Simkiss, D, Thorogood, Margaret, Stallard, Nigel, Lang, R, Kirby, J. (Joanna), Stallard, N, Hamborg, T, Poole, Francine, Rye, G. (Gloria), Khan, Kamran, Griffiths, F, Thorogood, M, Reddington, K, Khan, KA, Stewart-Brown, Sarah L., Petrou, S, Kirby, J, Robertson, W, Lang, R. (Rebecca), Rye, G, Robertson, Wendy, Stewart-Brown, S, Poole, F, Simkiss, Douglas E., Griffiths, Frances, Hamborg, Thomas   +27 more
core   +1 more source

Efficacy and safety of systemic morphine for persistent breathlessness in adults with advanced nonmalignant disease: a systematic review and meta-analysis of randomized trials

Palliative Medicine in Practice
BACKGROUND: Morphine is used for persistent breathlessness despite uncertainty about its efficacy and safety in advanced nonmalignant diseases. We evaluated its symptomatic, functional, physiologic, and adverse effects. METHODS: We conducted a systematic
Roxana Valentina Barrezueta Román, Alexandra Elizabeth Rosales Cevallos, Ronald Manuel Palma Sanchez   +2 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Strategies to improve recruitment to randomised controlled trials [PDF]

, 2010
Background Recruiting participants to trials can be extremely difficult. Identifying strategies that improve trial recruitment would benefit both trialists and health research.
Marie Pitkethly, Jones, R, Elizabeth Mitchell, Cook, Jonathan, Shaun Treweek, Treweek, S, Kjeldstrom, Monica, Sue Wilson, Johansen, Marit, Cook, J, Lockhart, Pauline, Taskila, Taina, Pauline Lockhart, Pitkethly, Marie, Kjeldstrom, M, Treweek, Shaun, Sullivan, F, Jackson, Catherine Miriam, Monica Kjeldstrøm, Marit Johansen, Mitchell, Elizabeth, Taina K Taskila, Mitchell, E, Sullivan, Frank, Jackson, Catherine, Johansen, M, Catherine Jackson, Ritu Jones, Wilson, Sue, Frank Sullivan, Jackson, C, Taina Taskila, Jones, Ritu, Pitkethly, M, Jonathan Cook   +34 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Acupoints Stimulation for Anxiety and Depression in Cancer Patients: A Quantitative Synthesis of Randomized Controlled Trials [PDF]

, 2016
This study aims at concluding the current evidence on the therapeutic effects of acupoints stimulation for cancer patients with anxiety and depression.
Deng, Renli, Guan, Feng-Guang, Wang, Tao, Tan, Jing-Yu   +3 more
core   +1 more source