Results 71 to 80 of about 43,824,661 (311)

The challenges faced in the design, conduct and analysis of surgical randomised controlled trials [PDF]

, 2009
Randomised evaluations of surgical interventions are rare; some interventions have been widely adopted without rigorous evaluation. Unlike other medical areas, the randomised controlled trial (RCT) design has not become the default study design for the
Jonathan A Cook, Cook, Jonathan Alistair, Cook, JA, Cook Jonathan A   +3 more
core   +2 more sources

Contamination in trials of educational interventions [PDF]

, 2007
Objectives: To consider the effects of contamination on the magnitude and statistical significance (or precision) of the estimated effect of an educational intervention, to investigate the mechanisms of contamination, and to consider how contamination ...
Keogh-Brown, M.R., Bachmann, M.O., Ramsay, Craig R, Hewitt, C., Campbell, M.J., Torgerson, D.J., Miles, J.N.V., Howe, A., Shepstone, L., Elbourne, Diana R., Song, F, Harvey, I., Miles, S.   +12 more
core   +3 more sources

Topical tetracaine prior to arterial puncture: a randomized, placebo-controlled clinical trial [PDF]

Respiratory Medicine, 2003
The objective of this randomized, double-blind, placebo-controlled clinical trial was to determine whether a topical anesthetic agent (tetracaine) provides effective local analgesia prior to radial arterial puncture. Tetracaine or placebo gel was applied 45 min prior to arterial puncture to patients who were referred for elective arterial blood gas ...
Aaron, Shawn D, Vandemheen, Katherine L, Naftel, Sheila A, Lewis, Mary-Jo, Rodger, Marc A   +4 more
openaire   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Functional Relaxation and Guided Imagery as Complementary Therapy in Asthma: A Randomized Controlled Clinical Trial [PDF]

, 2009
Background: Asthma is a frequently disabling and almost invariably distressing disease that has a high overall prevalence. Although relaxation techniques and hypnotherapeutic interventions have proven their effectiveness in numerous trials, relaxation ...
N. Sauer, F. Röhricht, D. Nowak, Loew, T., C. Lahmann, T. Schuster, Sauer, N., Nowak, Dennis, K. Tritt, M. Nickel, T. Loew, Ronel, J., M. Noll-Hussong, Schuster, T., Tritt, K., Noll-Hussong, M., J. Ronel, Lahmann, Claas, Lahmann, C., Röhricht, F., Nickel, M., Nowak, D., Lahmann, C.;Nickel, M.;Schuster, T.;Sauer, N.;Ronel, J.;Noll-Hussong, M.;Tritt, K.;Nowak, D.;Röhricht, F.;Loew, T., Lahmann, C;Nickel, M;Schuster, T;Sauer, N;Ronel, J;Noll-Hussong, M;Tritt, K;Nowak, D;Rohricht, F;Loew, T   +23 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The effectiveness of alcohol screening and brief intervention in emergency departments: A multicentre pragmatic cluster randomized controlled trial [PDF]

, 2014
Background Alcohol misuse is common in people attending emergency departments (EDs) and there is some evidence of efficacy of alcohol screening and brief interventions (SBI).
Patton, Robert, Dale, V, Eileen Kaner (588847), Deluca Paolo, Drummond, Colin, Gilvarry Eilish, Eilish Gilvarry (588836), Newbury-Birch, Dorothy, Touquet Robin, Judy Myles (588839), Martin Bland (222260), Colin Drummond (339336), Mike Crawford, Cassidy, P, Deluca, Paolo; id_orcid, Patton, R, Bland, Martin, Shepherd Jonathan, Newbury-Birch Dorothy, Eileen Kaner, Adenekan Oyefeso, Myles Judy, Steve Parrott, Heather, Nick, Oyefeso, Adenekan, Parrott, Steve, Colin Drummond, Ruth McGovern, Katherine Perryman, Coulton, S, Patton Robert, Nick Heather (588837), Perryman, K, Paolo Deluca, Steve Parrott (588841), Dorothy Newbury-Birch (588840), Dale, Veronica, Myles, J, Cassidy, Paul, Tom Phillips, Godfrey Christine, Kaner, E, Newbury-Birch, D, Oyefeso, A, Cassidy Paul, Simon Coulton, Robin Touquet (588846), Drummond Colin, Heather Nick, Veronica Dale (588835), Jonathan Shepherd (588845), McGovern Ruth, Oyfeso, Adenekan, Touquet, R, Perryman Katherine, Shepherd, Jonathan, Parrott, S, Phillips, T, Veronica Dale, Paolo Deluca (588833), Christine Godfrey (227956), Paul Cassidy (588834), Ruth McGovern (588838), Adenekan Oyefeso (18454), Godfrey, Christine, Myles, Judy, Jonathan Shepherd, Robin Touquet, Parrott Steve, Christine Godfrey, Perryman, Katherine, Phillips, Tom, Oyefeso Adenekan, Katherine Perryman (588843), Tom Phillips (588844), Judy Myles, Drummond, C, Heather, N, Deluca, Paolo, Coulton, Simon, Coulton Simon, Kaner Eileen, Simon Coulton (167071), Newbury-Birch, Dorothy; id_orcid, Drummond, Colin; id_orcid, Nick Heather, Phillips Tom, Crawford, M, Dorothy Newbury-Birch, Mike Crawford (282626), Bland Martin, Crawford Mike, Dale Veronica, Touquet, Robin, Gilvarry, Eilish, Kaner, Eileen, Robert Patton (588842), McGovern, Ruth, McGovern, R, Patton, Bob, Martin Bland, Crawford, Mike, Torquet, Robin, Robert Patton, Shepherd, J, Philips, Tom, Gilvarry, E, Eilish Gilvarry, Deluca, P, Godfrey, C, Paul Cassidy, Bland, M   +111 more
core   +1 more source

A Randomized Controlled Trial on the Hemostasis of Femoral Artery Using Topical Hemostatic Agent [PDF]

Clinical and Applied Thrombosis/Hemostasis, 2012
Objective: Evaluation of the effect of using a topical hemostatic agent named “ChitoHem ® ” on different factors on patients undergoing diagnostic coronary angiography. Methods: The present blind, randomized, controlled study included 124 patients randomly divided into 2 groups.
Soheila S, Kordestani, Fereidoon, Noohi, Hossein, Azarnik, Hossein, Basiri, M J, Hashemi, S, Abdi, A, Mohebi, M, Madani, Farzaneh, Nayebhabib   +8 more
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source