Results 41 to 50 of about 43,824,661 (311)

A statistical framework for quantifying clinical equipoise for individual cases during randomized controlled surgical trials [PDF]

, 2011
Background Randomised controlled trials are being increasingly used to evaluate new surgical interventions. There are a number of problematic methodological issues specific to surgical trials, the most important being identifying whether patients are ...
Girling, Alan, Girling Alan, Parsons, Nicholas R., Parsons, NR, Alan Girling, Griffin Damian, Girling, Alan J., Yuri Kulikov, Kulikov Yuri, Damian Griffin, Parsons Nicholas R, Griffin, Damian R., Griffin, D, Kulikov, Y, Kulikov, Yuri, Nicholas R Parsons   +15 more
core   +2 more sources

A capability framework to inform the fundamental requirements for clinical trial unit development, growth and long term success in outer metropolitan and rural areas

Contemporary Clinical Trials Communications, 2023
Background: Participation in clinical trials is linked to improved patient outcomes. Despite this, most trial participants either reside in, or are treated in metropolitan areas.
Anne Woollett, Jhodie Duncan, Mark Voskoboynik, Mark Shackleton, Michael Dooley, Robert Blum, Narelle McPhee, Tricia Wright, Zee Wan Wong, Jacqueline Dixon, Stephen M. Jane   +10 more
doaj   +1 more source

Strategies to improve recruitment to randomised controlled trials [PDF]

, 2010
Background Recruiting participants to trials can be extremely difficult. Identifying strategies that improve trial recruitment would benefit both trialists and health research.
Marie Pitkethly, Jones, R, Elizabeth Mitchell, Cook, Jonathan, Shaun Treweek, Treweek, S, Wilson, S, Kjeldstrøm, M, Kjeldstrom, Monica, Sue Wilson, Taskila, T, Johansen, Marit, Cook, J, Lockhart, Pauline, Taskila, Taina, Pauline Lockhart, Pitkethly, Marie, Taskil, T, Kjeldstrom, M, Treweek, Shaun, Sullivan, F, Cook, JAC, Jackson, Catherine Miriam, Monica Kjeldstrøm, Marit Johansen, Mitchell, Elizabeth, Taina K Taskila, Mitchell, E, Sullivan, Frank, Jackson, Catherine, Taskila, Taina K., Johansen, M, Catherine Jackson, Ritu Jones, Wilson, Sue, Mitchell, Lizabeth, Frank Sullivan, Jackson, C, Taina Taskila, Jones, Ritu, Pitkethly, M, Jonathan Cook   +41 more
core   +1 more source

Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression [PDF]

, 2012
Background: Randomized, double-blind, placebo-controlled trials constitute the gold standard in clinical research when testing the efficacy of new psychopharmacological interventions in the treatment of major depression.
Berger Michael, Dittmann, Sandra, Riedel Michael, Sophia, Frangou, Emanuel Severus, Bauer Michael, Severus, Emanuel, Pfennig Andrea, Florian Seemüller, Sophia Frangou, Michael, Bauer, Michael Bauer, Michael Riedel, Berger, Michael, Michael, Obermeier, Andrea, Pfennig, Michael Obermeier, Obermeier Michael, Seemüller Florian, Andrea Pfennig, Michael Berger, Hans-Jürgen, Möller, Dittmann Sandra, Michael, Riedel, Severus Emanuel, Frangou Sophia, Seemüller, Florian, Möller Hans-Jürgen, Sandra Dittmann, Hans-Jürgen Möller   +29 more
core   +2 more sources

Wound healing effects of topical Vitamin K: A randomized controlled trial

Indian Journal of Pharmacology, 2019
The incidence of acute and chronic wounds has rapidly increased which treatment remains as health problem. Previously, we reported the healing effect of Vitamin K in experimental animal models. The aim of this study was to investigate the effects of topical Vitamin K on skin wound healing process in patients.Sixty-three patients with indication for ...
Pazyar, Nader, Houshmand, Gholamreza, Yaghoobi, Reza, Hemmati, Ali Asghar, Zeineli, Zahra, Ghorbanzadeh, Behnam   +5 more
openaire   +3 more sources

Questions asked and answered in pilot and feasibility randomized controlled trials [PDF]

, 2011
Background In the last decade several authors have reviewed the features of pilot and feasibility studies and advised on the issues that should be addressed within them.
Shanyinde Milensu, Shanyinde, Milensu, Shanyinde, M, Weatherall, M., Weatherall, M, Mark Weatherall, Ruth M Pickering, Pickering, R.M., Shanyinde, M., Pickering Ruth M, Weatherall Mark, Pickering, RM, Milensu Shanyinde   +12 more
core   +2 more sources

OnabotulinumtoxinA for neurogenic detrusor overactivity and dose differences: a systematic review

International Brazilian Journal of Urology, 2015
Purpose To evaluate the efficacy and safety of onabotulinumtoxinA for patients with neurogenic detrusor overactivity (NDO). Materials and Methods We searched the Cochrane Library, PUBMED, EMBASE, Chinese Bio-medicine database, China Journal Full-text ...
Rui Zhang, Yongteng Xu, Shengping Yang, Hui Liang, Yunxin Zhang, Yali Liu   +5 more
doaj   +1 more source

Implementation of a nurse-led self-management support intervention for patients with cancer-related pain: a cluster randomized phase-IV study with a stepped wedge design (EvANtiPain)

BMC Cancer, 2020
Background Pain self-management support interventions were effective in controlled clinical trials and meta analyses. However, implementation of these complex interventions may not translate into identical effects. This paper evaluates the implementation
Silvia Raphaelis, Florian Frommlet, Hanna Mayer, Antje Koller   +3 more
doaj   +1 more source

Oral versus topical tamoxifen in cyclical mastalgia—A randomized controlled trial

The Breast Journal, 2019
Mastalgia affects premenopausal in which cyclical mastalgia affects up to 40% of women. In approximately 8% of these women, pain will be severe and interfere with their normal activities. oral tamoxifen widely used in the treatment of mastalgia is associated with a wide range of side effects. Topical tamoxifen has the potential to be a more efficacious
Divya Dhananjay Singh, Kadambari Dharanipragada, Shanmugam D, S. Manikandan   +3 more
openaire   +2 more sources

Evaluation of the effectiveness and cost-effectiveness of Families for Health V2 for the treatment of childhood obesity : study protocol for a randomized controlled trial [PDF]

, 2013
Background: Effective programs to help children manage their weight are required. Families for Health focuses on a parenting approach, designed to help parents develop their parenting skills to support lifestyle change within the family.
Petrou, Stavros, Reddington, Kate, Simkiss, D, Thorogood, Margaret, Stallard, Nigel, Lang, R, Kirby, J. (Joanna), Stallard, N, Hamborg, T, Poole, Francine, Rye, G. (Gloria), Khan, Kamran, Griffiths, F, Thorogood, M, Reddington, K, Khan, KA, Stewart-Brown, Sarah L., Petrou, S, Kirby, J, Robertson, W, Lang, R. (Rebecca), Rye, G, Robertson, Wendy, Stewart-Brown, S, Poole, F, Simkiss, Douglas E., Griffiths, Frances, Hamborg, Thomas   +27 more
core   +1 more source