Results 81 to 90 of about 346,597 (387)

Complementary religious and spiritual interventions in physical health and quality of life: A systematic review of randomized controlled clinical trials

open access: yesPLoS ONE, 2017
Objective To examine whether religious and spiritual interventions (RSIs) can promote physical health and quality of life in individuals. Methods The following databases were used to conduct a systematic review: PubMed, Scopus, Web of Science, EMBASE ...
J. P. Gonçalves   +3 more
semanticscholar   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Efficacy and safety of 0.5% colchicine cream versus 5% 5-fluorouracil cream in the treatment of cutaneous field cancerization: a randomized clinical trial [PDF]

open access: yesAnais Brasileiros de Dermatologia
Background 5-Fluorouracil (5-FU) is a first-line drug to treat cutaneous field cancerization (CFC). There are few clinical trials with topical colchicine (COL).
Amanda Soares Teixeira   +3 more
doaj   +1 more source

Transdermal Maltose-Based Microneedle Patch as Adjunct to Enhance Topical Anesthetic before Intravenous Cannulation of Pediatric Thalassemic Patients Receiving Blood Transfusion: A Randomized Controlled Trial Protocol

open access: yesJournal of Clinical Medicine, 2022
Intravenous cannulation is experientially traumatic to children. To minimize this, EMLA® is applied on the would-be-cannulated area before IV cannula insertion. However, the time to achieve its maximum efficacy may be affected due to incomplete cutaneous absorption and the duration of application.
Muhammad Irfan Abdul Jalal   +12 more
openaire   +2 more sources

Non-Inferiority Trials in Surgical Oncology [PDF]

open access: yes, 2018
The classical randomized controlled clinical trial is designed to prove superiority of an investigational therapy over an established therapy or placebo (here referred to as "superiority trial”).
Adamina, Michel   +2 more
core  

Development of an integrated cognitive behavioral therapy for anxiety and opioid use disorder: Study protocol and methods [PDF]

open access: yes, 2017
Opioid use disorder is a highly disabling psychiatric disorder, and is associated with both significant functional disruption and risk for negative health outcomes such as infectious disease and fatal overdose. Even among those who receive evidence-based
Barlow, David H.   +5 more
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Importance of achieving the composite endpoints in diabetes

open access: yesIndian Journal of Endocrinology and Metabolism, 2013
Well-conducted randomized controlled trials are instrumental in providing vital data on safety and efficacy of new molecules under consideration for approval. However acquiring such data involves huge cost and focused scientific endeavor.
Ambika Gopalakrishnan Unnikrishnan   +5 more
doaj   +1 more source

Nutritional factors associated with acne vulgaris [PDF]

open access: yes, 2016
Acne Vulgaris is a common dermatological condition defined as a chronic inflammatory dermatosis of the pilosebaceous unit that affects more than 17 million Americans.^1 Although it is not considered a dangerous condition, it may drastically impair ...
Patton, Elaura Elizabeth
core   +1 more source

Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery. [PDF]

open access: yes, 2011
BACKGROUND: Stroke is the major cause of adult disability. Selective serotonin reuptake inhibitors (SSRIs) have been used for many years to manage depression.
Anne Claxton   +6 more
core   +1 more source

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