Results 81 to 90 of about 1,683,394 (322)

Probiotics for the Treatment of Atopic Dermatitis in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Frontiers in Cellular and Infection Microbiology, 2017
Objective: Atopic dermatitis (AD) is a prevalent, burdensome, and psychologically important pediatric concern. Probiotics have been suggested as a treatment for AD.
Ruixue Huang, Huacheng Ning, M. Shen, Jie Li, Jianglin Zhang, Xiang Chen   +5 more
semanticscholar   +1 more source

Importance of achieving the composite endpoints in diabetes

Indian Journal of Endocrinology and Metabolism, 2013
Well-conducted randomized controlled trials are instrumental in providing vital data on safety and efficacy of new molecules under consideration for approval. However acquiring such data involves huge cost and focused scientific endeavor.
Ambika Gopalakrishnan Unnikrishnan, Arpandev Bhattacharyya, Manash Pratim Baruah, Binayak Sinha, Mala Dharmalingam, Paturi V Rao   +5 more
doaj   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Complementary religious and spiritual interventions in physical health and quality of life: A systematic review of randomized controlled clinical trials

PLoS ONE, 2017
Objective To examine whether religious and spiritual interventions (RSIs) can promote physical health and quality of life in individuals. Methods The following databases were used to conduct a systematic review: PubMed, Scopus, Web of Science, EMBASE ...
J. P. Gonçalves, G. Lucchetti, P. Menezes, H. Vallada   +3 more
semanticscholar   +1 more source

Effects of auriculotherapy on blood pressure levels in hypertensive adults and older adults

Rev Rene
Objective: to evaluate the effect of auriculotherapy on blood pressure and well-being parameters in hypertensive adults and older adults. Methods: a quasi-experimental, before-and-after study of a group undergoing a course of auriculotherapy. The initial
Victor Hugo Martins Santos, Margani Cadore Weis-Maia, Camila Maria Cenzi, Jaqueline Costa Lima, Camila de Souza dos Santos, Marina Nolli Bittencourt   +5 more
doaj   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Timing of tracheotomy in ICU patients: a systematic review of randomized controlled trials

Critical Care, 2015
IntroductionThe optimal timing of tracheotomy in critically ill patients remains a topic of debate. We performed a systematic review to clarify the potential benefits of early versus late tracheotomy.MethodsWe searched PubMed and CENTRAL for randomized ...
K. Hosokawa, M. Nishimura, M. Egi, J. Vincent   +3 more
semanticscholar   +1 more source

A Randomized Controlled Trial on the Hemostasis of Femoral Artery Using Topical Hemostatic Agent [PDF]

Clinical and Applied Thrombosis/Hemostasis, 2012
Objective: Evaluation of the effect of using a topical hemostatic agent named “ChitoHem®” on different factors on patients undergoing diagnostic coronary angiography. Methods: The present blind, randomized, controlled study included 124 patients randomly divided into 2 groups.
Soheila S. Kordestani, Hossein Ali Basiri, Mahboobeh Madani, Fereidoon Noohi, Farzaneh NayebHabib, Seyfollah Abdi, A. Mohebi, Hossein Azarnik, M. J. Hashemi   +8 more
openaire   +3 more sources

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Protein Diet Restriction Slows Chronic Kidney Disease Progression in Non-Diabetic and in Type 1 Diabetic Patients, but Not in Type 2 Diabetic Patients: A Meta-Analysis of Randomized Controlled Trials Using Glomerular Filtration Rate as a Surrogate

PLoS ONE, 2015
Background/ Objective Studies, including various meta-analyses, on the effect of Protein Diet Restriction on Glomerular Filtration Rate (GFR) in Chronic Kidney Disease (CKD) have reported conflicting results.
Mahesh Shumsher Rughooputh, R. Zeng, Ying Yao   +2 more
semanticscholar   +1 more source