Results 61 to 70 of about 1,011,036 (303)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

On Mangat's improved randomized response strategy

Statistica, 2007
In this paper, an alternative to the Mangat (1994) randomized response sampling procedure for estimating the proportion of human population possessing a sensitive characteristic is suggested.
Housila P. Singh, N. Mathur
doaj   +1 more source

Altruistic donation to improve survey responses: a global randomized trial

BMC Research Notes, 2019
Objective Web-based platforms have revolutionized the ability for researchers to perform global survey research. Methods to incentivize participation have been singularly focused on European and North American participants with varied results.
Andrew J. Cohen, Sam Washington, Christi Butler, Puneet Kamal, German Patino, Anas Tresh, Jorge Mena, Medina Ndoye, Benjamin N. Breyer   +8 more
doaj   +1 more source

Portal vein thrombosis and arterioportal shunts : effects on tumor response after chemoembolization of hepatocellular carcinoma

, 2011
AIM: To evaluate the effect of portal vein thrombosis and arterioportal shunts on local tumor response in advanced cases of unresectable hepatocellular carcinoma treated by transarterial chemoembolization.
Ackermann, Hans, Mohammed, Nour-Eldin Abdelrehim Nour-Eldin, Trojan, Jörg, Emad-Eldin, Sally, Abdelaziz, Omar, Naguib, Nagy Naguib Naeem, Vogl, Thomas J.   +6 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

CONSORT for Reporting Randomized Controlled Trials in Journal and Conference Abstracts: Explanation and Elaboration

, 2008
BACKGROUND: Clear, transparent, and sufficiently detailed abstracts of conferences and journal articles related to randomized controlled trials (RCTs) are important, because readers often base their assessment of a trial solely on information in the ...
Hopewell, S, Douglas G Altman, Moher, D., Mike Clarke, Schulz, KF, Hopewell, S., Wager, E., Philippa Middleton, The, CG, Sally Hopewell, Schulz, K., Moher, D, Altman, DG, CONSORT Group, Middleton, P, Clarke, M., Hopewel, S, Kenneth F Schulz, Elizabeth Wager, Wager, E, Middleton, P., Hopewell, Sally, David Moher, Altman, D., null null, Clarke, Michael, Clarke, M   +26 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Evaluating rule breaking behavior in a Nigerian protected forest reserve area

Journal of Applied Sciences and Environmental Management, 2019
This paper investigated the rule breaking conduct in a Nigerian protected forest reserve area in order to exploit natural resources using Randomized Response Technique (RRT) for data collection.
O.A. Akinsorotan, B.G. Oguntuase, O.E. Olaniyi, S.S. Nnamuka   +3 more
doaj   +1 more source

A new Tripartite Randomized Response Technique

, 2013
In any research involving sensitive questions, respondents tend to refuse to answer such questions or give evasive response. Many randomized response sampling techniques were developed but could only handle two answer options; ‘Yes’ and ‘No’, among which
Datti, Abdulkadir, Aminu, Abdulhadi, Adepetun, AO, Adebola, FB   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source