Results 91 to 100 of about 258,588 (291)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

A New Estimator based on Auxiliary Information through Quantitative Randomized Response Techniques

, 2017
An exponential-type estimator is developed for the population mean of the sensitive study variable based on various Randomized Response Techniques (RRT) using a non-sensitive auxiliary variable.
Özgül, N, Özgül, Nilgün, Çingi, H., Çıngı, Hülya, Nilgün Özgül, Hülya Çıngı   +5 more
core   +2 more sources

Ovarian Activation Surgical Techniques for Women with Premature Ovarian Insufficiency or Poor Ovarian Response: A Systematic Review [PDF]

International Journal of Fertility and Sterility
Background: In vitro fertilization (IVF) with egg donation often stands as the sole treatment option for women with premature ovarian insufficiency (POI) or poor ovarian response (POR); for this reason, alternative techniques are being developed, among ...
Antonio D'Amato, Antonio Simone Laganà, Amerigo Vitagliano, Antonio Stanziano, Anna Maria Caringella, Clementina Cantatore, Giuseppe D’Amato, Giovanni Buzzaccarini, Andrea Etrusco   +8 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Two new nonrandomized response models for surveys on sensitive topics

Survey Research Methods
If the direct questioning in surveys on sensitive variables leads to non-ignorable nonresponse and untruthful answers, a considerably biased estimator might be the consequence.
Andreas Quatember
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Trataka: A Promising Intervention to Reduce Anxiety in Children? A Randomized Controlled Trial with Cognitive and Electrodermal Measures

International Journal of Yoga
Background: One in five children suffers crippling dental anxiety, and traditional calming methods often fall short. Trataka, an ancient yogic technique, offers a powerful new approach to manage this anxiety.
Parth Rajesh Pandya
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Innovative improvements in randomized response models

, 2019
The estimation of the relative size of a certain subgroup within a population under study is one of the most important tasks in statistical surveys. When the question on the membership of the subgroup is sensitive, for example, membership in a group in ...
Yennum, Niharika
core