Results 71 to 80 of about 258,588 (291)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Comparative Study of Modified Hidden Logits Using Randomized Response Techniques

, 2022
The survey sampling is one of the driving and most extensively used technique to collect the data about individual’s behaviors, beliefs, views and opinions on a certain matter or topic.
Arshad, Irshad Ahmad, Shair, Waqas, Haroon, Summaira, Halim, Asma   +3 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Crafting an ingenious randomized response model for diverse questioning tactics

Franklin Open
When inquiries touch upon sensitive subjects like gambling habits, drug addiction, alcoholism, tendencies toward tax evasion, induced abortions, drunk driving, previous involvement in criminal activities, or matters related to sexuality in the context of
Manzoor A. Khanday, Tanveer A. Tarray, Dilawar A. Bhat   +2 more
doaj   +1 more source

A Modified Stratified Randomized Response Techniques

, 2014
This paper presents a modification of Kim and Warde’s (2004) Stratified Warner’s Randomized Response Technique (SWRRT) and Kim and Elam’s (2007) Stratified Unrelated Question Randomized Response Technique with known distribution (SURRT) using optimal ...
Johnson, O.O., Adebola, F.B., Adegoke, N.A.   +2 more
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

On the Bayesian Estimation of Synthesized Randomized Response Techniques for Obtaining Sensitive Information

International Journal of Mathematics and Mathematical Sciences
The reduction of response bias in survey research is crucial ensuring that the collected data accurately represents the target population. In this study, the Bayesian Estimation of the Synthesized Random Response Technique (BESRRT) estimators are ...
Olusegun S. Ewemooje, Isaac O. Adeniyi, Femi B. Adebola, Wilford B. Molefe   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Kernel Density Estimation for Joint Scrambling in Sensitive Surveys

Mathematics
Randomized response models aim to protect respondent privacy when sampling sensitive variables but consequently compromise estimator efficiency.
Alvan Caleb Arulandu, Sat Gupta
doaj   +1 more source

Bayesian Techniques in Randomized Response

Przegląd Statystyczny. Statistical Review, 2009
The issue of truthfulness of the answers given to socially or personally sensitive questions appeared at the very beginning of the construction of the surveys. The respondents often try to avoid answering a sensitive question or they do not tell the truth.
openaire   +1 more source