Results 41 to 50 of about 255,654 (257)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Adaptive strategies in unrelated question randomized response techniques for sensitive data collection

Research in Statistics
When surveys involve sensitive issues-such as gambling habits, drug addiction, alcoholism, tax evasion, induced abortions, drunk driving, criminal history, or homosexuality non-response and response biases frequently occur, as respondents may be ...
Khalid Ul Islam Rather, Osama Abdulaziz Alamri, Tanveer Ahmad Tarry   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A novel randomized scrambling technique for mean estimation of a finite population

Heliyon
In recent decades, the randomized response technique has attracted researchers due to its usefulness in sensitive surveys. The randomized response procedure is used for the collection of responses on sensitive issues such as cheating in examination ...
Muhammad Azeem, Asadullah, Musarrat Ijaz, Sundus Hussain, Najma Salahuddin, Abdul Salam   +5 more
doaj   +1 more source

New Randomization Technique to Estimate the Population Mean of Quantitative Sensitive Variable [PDF]

International Journal of Mathematical, Engineering and Management Sciences
Sensitive topics such as workplace misconduct, corporate fraud, unethical decision-making, diversity and inclusion challenges, and leadership accountability often present significant obstacles in survey research.
Chandraketu Singh, Vijay Lakshmi Singh, Sanjay K. Singh   +2 more
doaj   +1 more source

Filtered Randomized Response Technique

Communications for Statistical Applications and Methods, 2006
Randomized response technique is a survey technique for eliminating evasive answer bias. This technique is popular in social survey for sensitive issues. In this paper we present a simple and obvious procedure for estimating the population proportion of a sensitive group. Here, we shows the weak point in the method of Kim and Warde (2005).
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Aiding the well celebrated Kuk's randomized response technique through auxiliary and prior information

Heliyon
Asking direct questions in face to face surveys about sensitive traits is an intricate issue. One of the solutions to this issue is the randomized response technique (RRT). Being the most widely used indirect questioning technique to obtain truthful data
Zawar Hussain, Ishtiaq Hussain, Salman A. Cheema, Kalim Ullah, Sultan Salem, Walid Emam, Yusra Tashkandy   +6 more
doaj   +1 more source

Bayesian Techniques in Randomized Response

Przegląd Statystyczny. Statistical Review, 2009
The issue of truthfulness of the answers given to socially or personally sensitive questions appeared at the very beginning of the construction of the surveys. The respondents often try to avoid answering a sensitive question or they do not tell the truth.
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source