Results 101 to 110 of about 4,824,427 (292)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Soil flooding filters evolutionary lineages of tree communities in Amazonian riparian forests
Ecology and EvolutionInundations in Amazonian black‐water river floodplain result in the selection of different tree lineages, thus promoting coexistence between species. We investigated whether Amazonian tree communities are phylogenetically structured and distributed along
Sthefanie do Nascimento Gomes deSouza +17 more
doaj +1 more source
A RANDOMNESS‐BASED THEODICY FOR EVOLUTIONARY EVILS
Zygon, 2017 We develop and knit together several theodicies in order to find a more complete picture of why certain forms of (nonhuman) animal suffering might be permitted by a perfect being.
doaj +2 more sources
Randomness Representation of Turbulence in Canopy Flows Using Kolmogorov Complexity Measures
Entropy, 2017 Turbulence is often expressed in terms of either irregular or random fluid flows, without quantification. In this paper, a methodology to evaluate the randomness of the turbulence using measures based on the Kolmogorov complexity (KC) is proposed.
Dragutin Mihailović +4 more
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Randomness of Eigenstates of Many-Body Quantum Systems
Entropy, 2019 The emergence of random eigenstates of quantum many-body systems in integrable-chaos transitions is the underlying mechanism of thermalization for these quantum systems.
Li-Zhen Sun, Qingmiao Nie, Haibin Li
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Altered Domain Functional Network Connectivity Strength and Randomness in Schizophrenia
Frontiers in Psychiatry, 2019 Functional connectivity is one of the most widely used tools for investigating brain changes due to schizophrenia. Previous studies have identified abnormal functional connectivity in schizophrenia patients at the resting state brain network level.
Victor M. Vergara +21 more
doaj +1 more source