Results 101 to 110 of about 63,228 (269)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
AgronomyDigital soil mapping has become increasingly important for large-scale soil organic carbon (SOC) assessments, yet the choice of accuracy assessment method significantly influences model performance interpretation.
Dorijan Radočaj +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Random Walks in a Random Environment
The Annals of Probability, 1975 Let $\{\alpha_n\}$ be a sequence of independent, identically distributed random variables with $0 \leqq \alpha_n \leqq 1$ for all $n$. The random walk in a random environment on the integers is the sequence $\{X_n\}$ where $X_0 = 0$ and inductively $X_{n+1} = X_n + 1, (X_n - 1)$, with probability $\alpha_{X_n}, (1 - \alpha_{X_n})$.
openaire +3 more sources
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Random Permutations, Random Sudoku Matrices and Randomized Algorithms
CoRR, 2013 Some randomized algorithms, used to obtain a random $n^2 \times n^2$ Sudoku matrix, where $n$ is a natural number, is reviewed in this study. Below is described the set $Π_n$ of all $(2n) \times n$ matrices, consisting of elements of the set $\mathbb{Z}_n =\{ 1,2,\ldots ,n\}$, such that every row is a permutation.
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Czy możemy wykazać istnienie zjawisk całkowicie przypadkowych?
Zagadnienia Filozoficzne w Nauce, 2018 I show how classical and quantum physics approach the problem of randomness and probability. Contrary to popular opinions, neither we can prove that classical mechanics is a deterministic theory, nor that quantum mechanics is a nondeterministic one.
Marek Kuś
doaj