Results 61 to 70 of about 62,622 (269)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Nonshared environment: Real but random
JCPP AdvancesBackground In the excitement about genomics, it is easy to lose sight of one of the most important findings from behavioural genetics: At least half of the variance of psychopathology is caused by environmental effects that are not shared by children ...
Robert Plomin
doaj +1 more source
Key Generation and Testing Based on Biometrics [PDF]
Al-Rafidain Journal of Computer Sciences and MathematicsCreating and testing a biometric key is a critical process used for security and identity verification .When using biometric traits such as fingerprints, facial features, iris patterns, earprints, and voice patterns, a unique key is created and linked to
Alaa AbdulRaheeM, shahd Abdulrhman Hasso
doaj +1 more source
Enhancing Chaos Complexity of a Plasma Model through Power Input with Desirable Random Features
Entropy, 2020 The present work introduces an analysis framework to comprehend the dynamics of a 3D plasma model, which has been proposed to describe the pellet injection in tokamaks.
Hayder Natiq +4 more
doaj +1 more source
Spectroscopy with Random and Displaced Random Ensembles [PDF]
Physical Review Letters, 2002 Due to the time reversal invariance of the angular momentum operator J^2, the average energies and variances at fixed J for random two-body Hamiltonians exhibit odd-even-J staggering, that may be especially strong for J=0. It is shown that upon ensemble averaging over random runs, this behaviour is reflected in the yrast states.
Velázquez, V., Zuker, A. P.
openaire +4 more sources
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Random projections of random manifolds
CoRR, 2016 45 pages, 9 ...
Subhaneil Lahiri +2 more
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
On Random Sums of Random Vectors
The Annals of Mathematical Statistics, 1965 To obtain the limit distribution of a sequence $T_n$ of random vectors, the $j$th component of $T_n$ being the sum of a random number $N_n^{(j)}$ of $j$th components of independent, identically distributed chance vectors $X_n$, it is first necessary to treat the special case where the $N_n^{(j)}$ are degenerate random variables. This is done in Section
openaire +3 more sources