Results 131 to 140 of about 6,495 (196)

The effect of camptothecin on nuclear RanGTP levels in HeLa cells

The FASEB Journal, 2013
Nuclear transport is essential for the survival of all cells. The flow of molecules passing through the nuclear envelope via nuclear pore complexes is mediated by the karyopherin protein family, consisting of importins and exportins to which cargo can bind. The directionality of nuclear transport is regulated by a small GTPase, Ran.
Amy Marie Steinheiser, Karen K. Resendes
openaire   +1 more source

Influenza virus ribonucleoprotein complexes gain preferential access to cellular export machinery through chromatin targeting.

PLoS Pathogens, 2011
In contrast to most RNA viruses, influenza viruses replicate their genome in the nucleus of infected cells. As a result, newly-synthesized vRNA genomes, in the form of viral ribonucleoprotein complexes (vRNPs), must be exported to the cytoplasm for ...
Geoffrey P Chase, Marie-Anne Rameix-Welti, Aurelija Zvirbliene, Gintautas Zvirblis, Veronika Götz, Thorsten Wolff, Nadia Naffakh, Martin Schwemmle   +7 more
doaj   +1 more source

Towards reconciling structure and function in the nuclear pore complex [PDF]

, 2018
The spatial separation between the cytoplasm and the cell nucleus necessitates the continuous exchange of macromolecular cargo across the double-membraned nuclear envelope.
Aebi, Ueli, Fahrenkrog, Birthe, Lim, Roderick   +2 more
core  

Hold on to your friends: dedicated chaperones of ribosomal proteins [PDF]

, 2017
Eukaryotic ribosomes are assembled from their components, the ribosomal RNAs and ribosomal proteins, in a tremendously complex, multi-step process, which primarily takes place in the nuclear compartment.
Kressler, Dieter, Mitterer, Valentin, Pertschy, Brigitte, Pillet, Benjamin   +3 more
core  

Roles of Tubulin Concentration during Prometaphase and Ran-GTP during Anaphase of Caenorhabditis elegans Meiosis

Life Science Alliance
Tubulin dimers concentrate within an ER spindle envelope because cytoplasmic organelles outside the envelope occupy significant volume. In many animal species, the oocyte meiotic spindle, which is required for chromosome segregation, forms without ...
Ting Gong, Karen L McNally, Siri Konanoor, Alma Peraza, Cynthia Bailey, Stefanie Redemann, Francis J McNally   +6 more
doaj   +1 more source

Understanding RanGTP dependent microtubule assembly : Idenification of DnaJB6 as a RanGTP regulated factor involved in microtubule organization during mitosis

, 2017
Three microtubule (MT) assembly pathways participate in the assembly of the bipolar spindle: the centrosomal pathway, the augmin dependent amplification pathway and the RanGTP/chromosome dependent pathway. To form the spindle, all these MTs are organized by various classes of motor proteins into two interdigitating antiparallel arrays with their minus ...
openaire   +1 more source

Σύγκριση δομών πρωτεϊνικού συμπλόκου και των μεμονομένων αλυσίδων του μετά από εξισορρόπηση με προσομοιώσεις μοριακής δυναμικής [PDF]

, 2009
Παρατηρήσεις έκδοσης: λείπει η σελίδα 32 από το φυσικό ...
Παπατζέλος, Σταύρος
core  

Ran-GTP assembles a specialized spindle structure for accurate chromosome segregation in medaka early embryos

Nature Communications
Despite drastic cellular changes during cleavage, a mitotic spindle assembles in each blastomere to accurately segregate duplicated chromosomes. Mechanisms of mitotic spindle assembly have been extensively studied using small somatic cells.
Ai Kiyomitsu, Toshiya Nishimura, Shiang Jyi Hwang, Satoshi Ansai, Masato T. Kanemaki, Minoru Tanaka, Tomomi Kiyomitsu   +6 more
doaj   +1 more source

Mechanism of RanGTP dependent microtubule assembly during mitosis

, 2014
Programa de doctorat en ...
openaire   +1 more source

Prefabrication of a ribosomal protein subcomplex essential for eukaryotic ribosome formation [PDF]

, 2016
Peña, Cohue, Schütz, Sabina, Fischer, Ute, Chang, Yiming, Panse, Vikram G   +4 more
core   +2 more sources