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Cimetidine and Ranitidine [PDF]
To the Editor.— Most physicians would agree that the development of H 2 -inhibitor drugs for peptic ulcer is a major advance in the treatment of this common disease. Furthermore, the physiological research stimulated by their availability has increased our understanding of ulcer pathogenesis.
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Drug Intelligence & Clinical Pharmacy, 1983
Ranitidine is a selective, competitive histamine H2-receptor antagonist recently approved by the Food and Drug Administration for use in the short-term treatment of active duodenal ulcers and gastric hypersecretory conditions. Ranitidine is four to ten times more potent than cimetidine on a molar basis in inhibiting stimulated gastric acid secretion ...
T S, Gaginella, J H, Bauman
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Ranitidine is a selective, competitive histamine H2-receptor antagonist recently approved by the Food and Drug Administration for use in the short-term treatment of active duodenal ulcers and gastric hypersecretory conditions. Ranitidine is four to ten times more potent than cimetidine on a molar basis in inhibiting stimulated gastric acid secretion ...
T S, Gaginella, J H, Bauman
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Headache: The Journal of Head and Face Pain, 1985
SYNOPSISFive patients developed severe headaches in close association with the use of ranitidine. Two required hospitalization and three had recurrence of headaches on rechallenge. One had exacerbation of classic migraine. Headaches varied from intermittent and throbbing to steady and continuous, and onset was 12 hours to several months after beginning
C M, Epstein, J, Klopper
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SYNOPSISFive patients developed severe headaches in close association with the use of ranitidine. Two required hospitalization and three had recurrence of headaches on rechallenge. One had exacerbation of classic migraine. Headaches varied from intermittent and throbbing to steady and continuous, and onset was 12 hours to several months after beginning
C M, Epstein, J, Klopper
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JAMA: The Journal of the American Medical Association, 1983
Ranitidine is an H2-receptor antagonist that was released recently for use in the treatment of acute duodenal ulcer disease, Zollinger-Ellison syndrome, and systemic mastocytosis with gastric hypersecretion. The pharmacokinetics, efficacy, adverse effects, and clinical utility of ranitidine are presented.
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Ranitidine is an H2-receptor antagonist that was released recently for use in the treatment of acute duodenal ulcer disease, Zollinger-Ellison syndrome, and systemic mastocytosis with gastric hypersecretion. The pharmacokinetics, efficacy, adverse effects, and clinical utility of ranitidine are presented.
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Annals of Internal Medicine, 1985
Excerpt To the editor: In the report by Bredfeldt and von Huene on another possible case of ranitidine hepatitis (1) two cited studies are misinterpreted.
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Excerpt To the editor: In the report by Bredfeldt and von Huene on another possible case of ranitidine hepatitis (1) two cited studies are misinterpreted.
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Genotoxicity of nitrosated ranitidine
Mutation Research Letters, 1989The genotoxicity of ranitidine, widely used in the therapy of peptic ulcers, and of nitrosated ranitidine was examined in test systems with the bacteria Salmonella typhimurium for gene mutations, and with the yeast Saccharomyces cerevisiae D7 for reverse mutations and gene conversion.
Zdenka Matijasevic+2 more
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Inotropic Effects of Ranitidine
Survey of Anesthesiology, 1990The purpose of this controlled study was to study the effect of cimetidine and ranitidine on the myocardium of 8 healthy male volunteers using systolic time intervals. Ranitidine caused a significant decrease in the QS2I, as from 40 min indicating a positive inotropic effect. There were no significant changes in heart-rate or blood-pressure.
M. van Wyk+3 more
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Annals of Internal Medicine, 1983
Ranitidine, a new H2-receptor blocking antihistamine, is pharmacokinetically similar to cimetidine, but its potency is about eightfold greater. The clinical response to ranitidine is more prolonged, largely because of potency and not kinetic advantage.
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Ranitidine, a new H2-receptor blocking antihistamine, is pharmacokinetically similar to cimetidine, but its potency is about eightfold greater. The clinical response to ranitidine is more prolonged, largely because of potency and not kinetic advantage.
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Ranitidine and Agranulocytosis
Annals of Internal Medicine, 1986Excerpt To the editor: The H2-receptor antagonist ranitidine hydrochloride (Zantac; Glaxo, Inc. , Research Triangle Park, North Carolina) has been used extensively for the treatment of gastrointest...
Linda I. Shields+3 more
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Annals of Internal Medicine, 1984
Excerpt To the editor: The newly available histamine (H2) receptor antagonist, ranitidine hydrochloride (Zantac; Glaxo Inc.
F. Michael Melewicz, Elizabeth Fernandes
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Excerpt To the editor: The newly available histamine (H2) receptor antagonist, ranitidine hydrochloride (Zantac; Glaxo Inc.
F. Michael Melewicz, Elizabeth Fernandes
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