Irbesartan Ameliorates Diabetic Nephropathy by Suppressing the RANKL-RANK-NF-κB Pathway in Type 2 Diabetic db/db Mice [PDF]
, 2016 Xiaowen Chen +10 more
openalex +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Combining RANK/RANKL and ERBB-2 targeting as a novel strategy in ERBB-2-positive breast carcinomas [PDF]
, 2019 Ilianna Zoi +7 more
openalex +1 more source
The Electronic Journal of Combinatorics, 2003 The rank of the adjacency matrix of a graph is bounded above by the number of distinct non-zero rows of that matrix. In general, the rank is lower than this number because there may be some non-trivial linear combination of the rows equal to zero. We show the somewhat surprising result that this never occurs for the class of cographs.
openaire +2 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The Stable Exotic Cuntz Algebras are Higher-Rank Graph Algebras [PDF]
, 2023 Jeffrey L. Boersema +2 more
openalex +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Performance Evaluation on Rank Adaptation of MIMO Transmission Method Using Probabilistic Interference Arrival Information Assuming Probability Prediction Error [PDF]
, 2023 Yusuke Okumoto +3 more
openalex +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
A matrix approach to determine optimal predictors in a constrained linear mixed model
Open MathematicsFor a general vector of all unknown vectors in a constrained linear mixed model (CLMM), this study compared the dispersion matrices of the best linear unbiased predictors with any symmetric matrix for determining the optimality of predictors among others.
Güler Nesrin, Büyükkaya Melek Eriş
doaj +1 more source