Results 71 to 80 of about 457,473 (310)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Visualisation and graph-theoretic analysis of a large-scale protein structural interactome

BMC Bioinformatics, 2003
Background Large-scale protein interaction maps provide a new, global perspective with which to analyse protein function. PSIMAP, the Protein Structural Interactome Map, is a database of all the structurally observed interactions between superfamilies of
Harrington Richard, Dafas Panos, Bolser Dan, Park Jong, Schroeder Michael   +4 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Graph-Theoretic Approach for Self-Testing in Bell Scenarios

PRX Quantum, 2022
Self-testing is a technology to certify states and measurements using only the statistics of the experiment. Self-testing is possible if some extremal points in the set B_{Q} of quantum correlations for a Bell experiment are achieved, up to isometries ...
Kishor Bharti, Maharshi Ray, Zhen-Peng Xu, Masahito Hayashi, Leong-Chuan Kwek, Adán Cabello   +5 more
doaj   +1 more source

Graph Theory Based N-1 Transmission Contingency Selection and Its Application in Security-constrained Unit Commitment

Journal of Modern Power Systems and Clean Energy, 2021
Contingency analysis is an important building block in the stability and reliability analysis of power grid operations. However, due to the large number of transmission lines, in practice only a limited number of contingencies could be evaluated.
Lu Nan, Yikui Liu, Lei Wu, Tianqi Liu, Chuan He   +4 more
doaj   +1 more source

A new graph based on the semi-direct product of some monoids [PDF]

, 2013
In this paper, firstly, we define a new graph based on the semi-direct product of a free abelian monoid of rank n by a finite cyclic monoid, and then discuss some graph properties on this new graph, namely diameter, maximum and minimum degrees, girth ...
Cangül, İsmail Naci, Das, Kinkar Chandra, Karpuz Güzel, Eylem, Çevik, Ahmet Sinan   +3 more
core   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

The topological structure of urban roads and its relation with human activities at the street-based community level

Frontiers in Earth Science, 2022
The topological structure of the underlying streets can help us better understand urban space and human activities therein. As human urban movements are inherently heterogenous in space and statistics, whether or not the network of streets holds a ...
Yan Zhang, Yebin Chen, Wei Zhu, Wenwen Wang, Qian Zhang   +4 more
doaj   +1 more source

Graph theory for analyzing pair-wise data: application to geophysical model parameters estimated from interferometric synthetic aperture radar data at Okmok volcano, Alaska

Journal of Geodesy, 2016
Graph theory is useful for analyzing time-dependent model parameters estimated from interferometric synthetic aperture radar (InSAR) data in the temporal domain.
Elena C. Reinisch, M. Cardiff, K. Feigl
semanticscholar   +1 more source

Modified Interior-Point Method for Large-and-Sparse Low-Rank Semidefinite Programs

, 2017
Semidefinite programs (SDPs) are powerful theoretical tools that have been studied for over two decades, but their practical use remains limited due to computational difficulties in solving large-scale, realistic-sized problems.
Lavaei, Javad, Zhang, Richard Y.
core   +1 more source