Results 131 to 140 of about 1,113,430 (306)
, 2013 A Kaplan-Meier analysis and log rank test on all patients (n = 306) proved patients with stronger staining of EMMPRIN had worse prognosis (log rank test ...
Li Tian (207552) +5 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Statistical approach for selection of regression model during validation of bioanalytical method [PDF]
Makedonsko Farmacevtski Bilten, 2014 The selection of an adequate regression model is the basis for obtaining accurate and reproducible results during the bionalytical method validation. Given the wide concentration range, frequently present in bioanalytical assays, heteroscedasticity of ...
Natalija Nakov +3 more
doaj
On Ranking-based Tests of Independence
In this paper we develop a novel nonparametric framework to test the independence of two random variables $\mathbf{X}$ and $\mathbf{Y}$ with unknown respective marginals $H(dx)$ and $G(dy)$ and joint distribution $F(dx dy)$, based on {\it Receiver Operating Characteristic} (ROC) analysis and bipartite ranking.
Limnios, Myrto, Clémençon, Stephan
openaire +4 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
On Property Testing of the Binary Rank.
, 2023 Let M be an n × m (0,1)-matrix. We define the s-binary rank, denoted as br_s(M), of M as the minimum integer d such that there exist d monochromatic rectangles covering all the 1-entries in the matrix, with each 1-entry being covered by at most s rectangles.
openaire +3 more sources
, 2013 Disease-free survival between basiliximab and steroid groups for (A) all recipients (log-rank test, P = 0.913); (B) recipients within Milan criteria (log-rank test, P = 0.022); (C) recipients within UCSF criteria (log-rank test, P = 0.079).
Tonghai Xing (442488) +5 more
core +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Performance of the modified Wilcoxon signed rank test
, 2014 Nonparametric methods require only few assumptions to be made about the format of the data, and they may therefore be preferable when the assumptions required for parametric methods are not valid.
Syed Yahaya, Sharipah Soaad +9 more
core +1 more source