Results 81 to 90 of about 1,113,430 (306)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Rank Test Based On Matrix Perturbation Theory [PDF]
In this paper, we propose methods of the determination of the rank of matrix. We consider a rank test for an unobserved matrix for which an estimate exists having normal asymptotic distribution of order N1/2 where N is the sample size. The test statistic
Zaka Ratsimalahelo
core +2 more sources
The Rasch-Model From an Individual’s Perspective: The Item Rank Plot and the Compensation Test
Journal for Person-Oriented Research, 2016 The present study takes a closer look at the principles of estimating person parameters in the Rasch-Model and how they can be utilized for assessing model fit.
Rainer W. Alexandrowicz
doaj +1 more source
The Annals of Mathematical Statistics, 1955 This paper suggests several `goodness of fit' test criteria, all having a linear form. The moment generating function and the limiting distribution of this linear form are obtained in Section 2. The best test criterion of this form for testing a simple hypothesis $H_0$ against a simple alternative hypothesis $H_1$ is shown, in Section 3, to be in ...
openaire +2 more sources
, 2014 Survival curves in 100 recurrent OSCC patients according to (A) CRP level (log rank test ...
Chun-Ta Liao (117115) +5 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
BioData Mining, 2018 Background Survival analysis is a statistical technique widely used in many fields of science, in particular in the medical area, and which studies the time until an event of interest occurs.
Eunice Carrasquinha +3 more
doaj +1 more source
Genome Biology, 2022 When identifying differentially expressed genes between two conditions using human population RNA-seq samples, we found a phenomenon by permutation analysis: two popular bioinformatics methods, DESeq2 and edgeR, have unexpectedly high false discovery ...
Yumei Li +4 more
doaj +1 more source
On Rank Aggregating Test Prioritizations
CoRR23 pages, 13 figures, technical ...
Shouvick Mondal, Tse-Hsun Chen
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source