Results 121 to 130 of about 1,465,496 (351)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Using Cox regression to develop linear rank tests with zero-inflated clustered data. [PDF]

J R Stat Soc Ser C Appl Stat, 2020
Lipsitz SR, Fitzmaurice GM, Sinha D, Cole AP, Meyer CP, Trinh QD.   +5 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

On rank estimation in semidefinite matrices [PDF]

This work concerns the problem of rank estimation in semidefinite matrices, having either indefinite or semidefinite matrix estimator satisfying a typical asymptotic normality condition.
Natércia Fortuna, Stephen G. Donald, Vladas Pipiras   +2 more
core  

Rank-Sum Tests for Dispersions

The Annals of Mathematical Statistics, 1960
This paper deals with non-parametric two-sample tests on dispersions. Two samples, $X$- and $Y$-samples of $m$ and $n$ independent observations from populations with continuous cumulative distribution functions $F(u)$ and $G(u)$ respectively, are considered.
Ansari, A. R., Bradley, R. A.
openaire   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Stratified modestly-weighted log-rank tests in settings with an anticipated delayed separation of survival curves [PDF]

, 2022
Dominic Magirr, José L. Jiménez
openalex   +1 more source

A Bivariate Signed Rank Test

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1964
Summary Wilcoxon (1945, 1947) proposed a signed rank test for the hypothesis of equality of means in samples of n matched pairs of observations from a bivariate population in (x, y). He stated the exact distribution of the sum (= U  +) of the signed ranks of the positive differences z = x - y, as well as providing some tables of the ...
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Pore structure as well as mechanical and seepage characteristics of hot-pressed coal briquettes with different coal ranks

Meitan xuebao
To address the problem that the strength and permeability of coal briquettes used in physical similarity simulation tests differ significantly from those of raw coal, this study investigates the pore structure, mechanical and seepage characteristics of ...
Jiang XU, Shoujian PENG, Xu WANG, Li JIA, Houqin HAN, Zhonghui WANG, Qingqing GAN   +6 more
doaj   +1 more source