Results 241 to 250 of about 1,456,756 (304)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Social rank and social environment combinedly affect REM sleep in mice. [PDF]
Sci RepHayashi N, Kawai A, Hayashi Y.
europepmc +1 more source
Efficacy of repeated self-guided digital cognitive behavioral therapy for chronic insomnia: A pilot open-label study following a previous RCT. [PDF]
Digit HealthZhang C, Liu Y, Guo X, Shen Y, Ma J.
europepmc +1 more source
Evaluating large language models in biomedical data science challenges through a classroom experiment. [PDF]
Proc Natl Acad Sci U S AMa H +2 more
europepmc +1 more source
Improving Visual Field Testing Reliability by Using an Educational Patient Leaflet. [PDF]
CureusSuresh B +2 more
europepmc +1 more source
Influence of Clinical Experience on Learning the Focused Assessment With Sonography for Trauma (FAST) Protocol: A Pilot Study. [PDF]
CureusQuintão CM, Domingues GP, Toledo A.
europepmc +1 more source