Results 261 to 270 of about 3,905,246 (313)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Multimodal Behavior Scoring Quantifies Depression-like Severity Across Chronic Stress Models and Identifies Stress-Resilient Mice. [PDF]

NeuroSci
Tu Y, Fu Q, Sun C, Deng J, Qin H, Zeng X, Wang Y, Qiu S, Zhang W.   +8 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Dimethyl sulfoxide perturbs sleep-related behavioral organization in multiple species and confounds interpretation of sleep phenotypes. [PDF]

Front Toxicol
Udo N, Sekiguchi M, Sawatari E, Itoh TQ.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Using sequence-derived microbiome information from bulk tank milk samples to assess the influence of post-milking teat disinfection in New Zealand dairy herds. [PDF]

Anim Microbiome
Ling H, Williamson J, Gatenby S, Pruden S, Neeley C, Harland C, Wallace A, Couldrey C.   +7 more
europepmc   +1 more source

Hip Hinge Kinematics and Movement Confidence Before and After Founder Exercise Instruction in Healthy Adults: A Preliminary Study. [PDF]

J Funct Morphol Kinesiol
Hanney WJ, Chase J, Coates T, Rodriguez-Rolas C, Massaracchio M, Anderson AW.   +5 more
europepmc   +1 more source

A rank-conditioned α-stable perturbation for differential evolution: Separating perturbation frequency and tail heaviness. [PDF]

PLoS One
Choi TJ, An Y.
europepmc   +1 more source