Results 81 to 90 of about 13,074 (260)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Education Quality Ranker: A Novel Internet-Scale, Graph-Learning-Based, and Multi-View Quality Model for College/Univeristy Ranking

IEEE Access
In the realm of higher education, accurately assessing and ranking the quality of educational offerings is crucial. The paper introduces “Education Quality Ranker,” an innovative framework designed to rank colleges and universities on an ...
Yunhua Chen
doaj   +1 more source

Enhanced Search Engine Using Proposed Framework and Ranking Algorithm Based on Semantic Relations

IEEE Access, 2019
Today, most users need search engines to facilitate search and information retrieval processes. Unfortunately, traditional search engines have a significant challenge that they should retrieve high-precision results for a specific unclear query at a ...
M. M. El-Gayar, N. E. Mekky, A. Atwan, H. Soliman   +3 more
doaj   +1 more source

Orthogeriatric co-management for proximal femoral fractures. Can two additions make a big difference?

BMC Musculoskeletal Disorders, 2020
Background Proximal femoral fractures are a major socioeconomic burden and they occur mainly in geriatric patients. High mortality and complication rates are reported.
Maic Werner, Olaf Krause, Christian Macke, Lambert Herold, Alexander Ranker, Christian Krettek, Emmanouil Liodakis   +6 more
doaj   +1 more source

Training a Ranking Function for Open-Domain Question Answering

, 2018
In recent years, there have been amazing advances in deep learning methods for machine reading. In machine reading, the machine reader has to extract the answer from the given ground truth paragraph.
Bowman, Samuel R., Cho, Kyunghyun, Htut, Phu Mon   +2 more
core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Top influencers can be identified universally by combining classical centralities

Scientific Reports, 2020
Information flow, opinion, and epidemics spread over structured networks. When using node centrality indicators to predict which nodes will be among the top influencers or superspreaders, no single centrality is a consistently good ranker across networks.
Doina Bucur
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

In-Silico Approach of Mole Crab (Emerita sp.) Peptides 3 Produced by Alcalase Hydrolysis

Squalen
One type of mole crab in Indonesia is Emerita sp., which has a fatty acid content of 3.57% and crude protein content of 32.42% (100 mg). The use of mole crabs is currently limited to food sources; therefore, it is necessary to conduct research to ...
Romadhon Romadhon, Agus Sabdono, Subagyo Subagyo, Agus Triyanto, Putut Har Riyadi, Ulfah Amalia   +5 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source