Results 101 to 110 of about 910,379 (294)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

On Loss Functions and Ranking Forecasting Performances of Multivariate Volatility Models [PDF]

open access: yes
A large number of parameterizations have been proposed to model conditional variance dynamics in a multivariate framework. However, little is known about the ranking of multivariate volatility models in terms of their forecasting ability.
Francesco Violante   +2 more
core  

Temporal Rank Functions for Forward Secrecy

open access: yes18th IEEE Computer Security Foundations Workshop (CSFW'05), 2005
A number of key establishment protocols claim the property of forward secrecy, where the compromise of a long-term key does not result in the compromise of previously computed session-keys. We describe how such protocols can be modelled using the process algebra CSP and explain why the well-known rank function approach is incapable of proving their ...
Delicata, Rob, Schneider, Steve A.
openaire   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Ranking efficient DMUs using cooperative game theory [PDF]

open access: yes, 2017
The problem of ranking Decision Making Units (DMUs) in Data Envelopment Analysis (DEA) has been widely studied in the literature. Some of the proposed approaches use cooperative game theory as a tool to perform the ranking.
Borrero Molina, Diego Vicente   +2 more
core  

Estimation of low-rank covariance function

open access: yesStochastic Processes and their Applications, 2016
We consider the problem of estimating a low rank covariance function $K(t,u)$ of a Gaussian process $S(t), t\in [0,1]$ based on $n$ i.i.d. copies of $S$ observed in a white noise. We suggest a new estimation procedure adapting simultaneously to the low rank structure and the smoothness of the covariance function.
Koltchinskii, V.   +2 more
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Dual Generalized Nonnegative Normal Neutrosophic Bonferroni Mean Operators and Their Application in Multiple Attribute Decision Making

open access: yesInformation, 2018
For multiple attribute decision making, ranking and information aggregation problems are increasingly receiving attention. In a normal neutrosophic number, the ranking method does not satisfy the ranking principle. Moreover, the proposed operators do not
Jiongmei Mo, Han-Liang Huang
doaj   +1 more source

Ranks For Two Partition Quadruple Functions [PDF]

open access: yesJournal de théorie des nombres de Bordeaux, 2017
Recently the author introduced two new integer partition quadruple functions, which satisfy Ramanujan-type congruences modulo 3, 5, 7, and 13. Here we reprove the congruences modulo 3, 5, and 7 by defining a rank-type statistic that gives a combinatorial refinement of the congruences.
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

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