Results 161 to 170 of about 12,421,662 (339)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Synthesizing Nested Ranking Functions for Loop Programs via SVM

open access: yesIEEE International Conference on Formal Engineering Methods, 2019
Yi Li   +4 more
semanticscholar   +1 more source

RANKING LACTATION CURVE FUNCTIONS, OF

open access: yes, 2002
: Ranking analysis was carried out on fourteen mathematical functions that have been used in the literature to describe the lactation curve. A total of 20831 test day records of milk yield were obtained biweekly during the period 1996-1999 on two dairy ...
M.S. Alkraidees   +2 more
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

On the rank functions of $\mathcal{H}$-matroids

open access: yesJournal of Algebra Combinatorics Discrete Structures and Applications, 2016
The notion of $\mathcal{H}$-matroids was introduced by U. Faigle and S. Fujishige in 2009 as a general model for matroids and the greedy algorithm. They gave a characterization of $\mathcal{H}$-matroids by the greedy algorithm. In this note, we give a characterization of some $\mathcal{H}$-matroids by rank functions.
openaire   +4 more sources

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

THE EFFICIENCY OF UNIVERSITY RANKINGS: IMPLEMENTATION OF INFORMATIONAL AND MOTIVATIONAL FUNCTIONS

open access: yesВысшее образование в России, 2016
Basing on their hypothesis and an analysis of foreign studies, the authors determine how the information and motivational functions of rankings impact on Russian universities students' choice. The results of students' awareness of university rankings and
Liliya R. Yagudina, Iskander I. Yagudin
doaj  

Feature Importance Ranking Using Interval-Valued Methods and Aggregation Functions for Machine Learning Applications

open access: yesApplied Sciences
Feature selection is one of the key stages in the process of creating machine learning models and conducting data analysis. This paper presents the results of research related to the implementation of a new algorithm for feature selection and ranking ...
Aleksander Wojtowicz   +2 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

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