Results 101 to 110 of about 35,367 (244)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A numerical study on the effects of high-lift devices on the aerodynamic characteristics of a large aircraft

Hangkong gongcheng jinzhan
The high-lift device of an aircraft can improve its lift and safety, and the reasonable application of the high-lift device is crucial to improving the safety of the aircraft.
ZHU Guowang, WU Hengbin, HUANG Shenghong, NI Zao   +3 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Topological optimization of the axial compressor blade of aircraft gas turbine engine

Авіаційно-космічна техніка та технологія
The requirements for the efficiency, reliability, and environmental friendliness of technical systems in modern mechanical engineering are constantly increasing.
Maryna Pikul, Kateryna Balalaieva, Anton Balalaiev, Andrii Melchenko   +3 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

RANS-based fast computational methods for indoor flows: a framework-driven performance assessment for a simple benchmark

Developments in the Built Environment
Reliable indoor climate prediction requires reliable tools. Complex airflow predictions often involve the use of physical or numerical models. Computational fluid dynamics (CFD) is a popular, high-fidelity method that can produce reliable predictions ...
Eugene Mamulova, Marcel Loomans, Twan van Hooff   +2 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Progress in Hybrid RANS-LES Modelling : Papers Contributed to the 3rd Symposium on Hybrid RANS-LES Methods, Gdansk, Poland, June 2009 /

, 2010
The present book contains contributions presented at the Third Symposium on Hybrid RANS-LES Methods, held in Gdansk, Poland, 10-12 June 2009, being a continuation of the first symposium taking place in Stockholm (Sweden, 2005) and the second in Corfu ...
Haase, Werner,edt, Symposium on Hybrid RANS-LES Methods3rd :2009 :Gdansk, Poland, Doerffer, Piotr,edt, Peng, Shia-Hui.,edt   +3 more
core  

Etude numérique de l’écoulement autour de l’éolienne NORDEX N80

Revue des Énergies Renouvelables, 2013
Une étude basée sur la résolution des équations moyennées de Navier-Stockes (RANS) écrites pour un écoulement bidimensionnel axisymétrique en régime stationnaire a été effectuée à l’aide du code saturne d’EDF pour caractériser l’écoulement autour d’une ...
M. Tata, A. Smaïli, O. Guerri
doaj  

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source