Results 81 to 90 of about 35,367 (244)
Numerical Investigating the Effect of Water Depth on Ship Resistance Using RANS CFD Method
Polish Maritime Research, 2019 On inland waterways the ship resistance and propulsive characteristics are strictly related to the depth of the waterway, thus it is important to have an understanding of the influence of water depth on ship hydrodynamic characteristics.
Hoa Nguyen Thi Ngoc +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Social-Aware Edge Caching in Fog Radio Access Networks
IEEE Access, 2017 Fog radio access networks (F-RANs) are becoming an emerging and promising paradigm for fifth generation cellular communication systems. In F-RANs, distributed edge caching techniques among remote radio heads (RRHs) and user equipment (UE) can effectively
Xiang Wang, Supeng Leng, Kun Yang
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Hybrid RANS/LES computation of plane impinging jet flow
Archives of Mechanics, 2011 Flow characteristics are presented of simulation results of plane impinging jets at high nozzle-plate distances, with two k-ω based hybrid RANS/LES (Reynolds Averaged Navier–Stokes/Large–Eddy Simulation) models and a k-ω RANS model. The first hybrid RANS/
S. Kubacki, J. Rokicki, E. Dick
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
The challenges of using radial inlet guide vanes for wide-range control of a centrifugal compressor [PDF]
EPJ Web of ConferencesRegions of significant performance degradation were observed in a single-stage centrifugal compressor tested on a dedicated industrial rig. The machine was operated under discharge throttling, variable impeller speed, and radial inlet guide vane control.
Hurda Lukáš +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
A RANS/LES Hybrid Model Based on Local Flow Structure
, 2014 针对传统雷诺平均Navier-Stokes/大涡模拟(RANS/LES)混合模型固有的RANS和LES区域衔接难题,借鉴Vreman提出的亚格子(SGS)模型,提取其中描述流动状态的判断函数,利用不可压缩槽道湍流标定模型系数,构造了一个新的RANS/LES混合模型。评估算例包括不可压缩槽道湍流、稳态超声速平板边界层、NACA4412翼型绕流和亚临界雷诺数圆柱绕流。该模型作为壁面模化LES,解决了传统RANS/LES方法中速度型偏离对数律(LLM)的缺陷,且拓宽了原Vreman模型在粗糙网格上的适用性 ...
杨焱, 徐晶磊, 高歌
core +2 more sources
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source