Results 71 to 80 of about 35,367 (244)
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Efficiency Improvements of RANS-Based Analysis and Optimization using Implicit and Adjoint Methods on Unstructured Grids [PDF]
, 2006 The efficiency of an unstructured grid finite volume RANS solver is signicantly improved using two implicit methods based on diering philosophies. The LU-SGS multigrid method aims to improve performance, while maintaining the low memory requirements and
Dwight, Richard
core
Ship wake field analysis using a coupled BEMt-RANS approach
The prediction of a ship’s wake field and self-propulsion capabilities has traditionally been centered on experiments; however with the advancement in modern computing power, this can be achieved through the use of computational methods.
Badoe, C., Turnock, S.R., Phillips, A.B.
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2008 This volume contains papers contributed to the Second Symposium on Hybrid RANS-LES Methods, held in Corfu, Greece, 17-18 June 2007. All the papers have undergone further review and revision after the symposium, which has covered a number of relevant ...
Haase, Werner, +4 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Data-Driven RANS Modeling With Data Augmentation
气体物理Guo et al.[1] proposed using implicit treatment with asynchronous iterations in Reynolds-averaged Navier-Stokes （RANS） simulations for training cases[2].
Chun BAO, Zhenhua XIA, Yipeng SHI
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source