Results 71 to 80 of about 116,766 (290)
New Attitude to the Great Silk Road
Проблемы постсоветского пространства, 2017 The Great Silk Road existed more than 2000 years and has played an important role in the development of civilizations and trade and economic relations.
I. S. Zonn, Uyichtzao Tjan
doaj
Aerodynamic Optimization of 3D Micro HAWT Blade via RSM [PDF]
Journal of Applied Fluid MechanicsThe goal of this research is to redesign the three-dimensional geometry of a micro horizontal-axis wind turbine blade using response surface methodology.
R. Bekkai, R. Mdouki, R. Laouar
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
RANS Turbulence Model Development using CFD-Driven Machine Learning
, 2020 This paper presents a novel CFD-driven machine learning framework to develop Reynolds-averaged Navier-Stokes (RANS) models. The CFD-driven training is an extension of the gene expression programming method (Weatheritt and Sandberg, 2016), but crucially ...
Akolekar, Harshal D. +4 more
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Simulation de l’écoulement autour d’un profil à l’aide d’une méthode DES
Revue des Énergies Renouvelables, 2015 Ce travail concerne l’étude du comportement d’un écoulement turbulent autour d’un profil d’aile NACA23012. Nous avons effectué des simulations numériques de l’écoulement.
F. Bourekba, O. Guerri, N. Nait Bouda
doaj
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Aerodynamic Response of a Hovering Rotor to Ramp Changes in Pitch Input [PDF]
, 2008 Under transient conditions, a helicopter rotor generates a complex, time-dependent pattern of shed and trailed vorticity in its wake that has profound eects on its loading.
Brown, R.E., Duraisamy, K.
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source