Rapamycin Destabilizes Interleukin-3 mRNA in Autocrine Tumor Cells by a Mechanism Requiring an Intact 3′ Untranslated Region [PDF]
, 1997 Rolf Banholzer +4 more
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Rapamycin for longevity: opinion article
Aging, 2019 From the dawn of civilization, humanity has dreamed of immortality. So why didn't the discovery of the anti-aging properties of mTOR inhibitors change the world forever? I will discuss several reasons, including fear of the actual and fictional side effects of rapamycin, everolimus and other clinically-approved drugs, arguing that no real side effects ...
openaire +3 more sources
A Novel nor@DHB Matrix for Direct Microbial Analysis in Lung Cancer Tissues
Advanced Science, EarlyView.Integrated matrix‐assisted laser desorption/ionization mass spectrometry workflow quantifies intratumoral microbes in lung cancer through lipopolysaccharide/lipid A extraction from biopsies. The novel ionic matrix called norharmane conjugated to 2,5‐dihydroxybenzoic acid enhances lipid A ionization, enabling direct detection of bacterial genera ...
Liang Shan +12 more
wiley +1 more source
Rapamycin: FK506's fraternal twin or distant cousin?
, 1991 Randall E. Morris
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In vivo inhibition of cytokine responsiveness and graft-versus-host disease mortality by rapamycin leads to a clinical-pathological syndrome discrete from that observed with cyclosporin A [PDF]
, 1996 BR Blazar +4 more
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Advanced Science, EarlyView.B‐OMVs, nanoscale vesicles derived from BCG, are identified as effective and safe inducers of trained immunity that protect against sepsis. Through TLR2‐mediated metabolic and epigenetic reprogramming of hematopoietic stem cells, B‐OMVs enhance inflammatory response and phagocytic activity.
Yuan Gong +16 more
wiley +1 more source
Autophagy‐Mediated Suppression of Tumor Growth by Food‐Grade Lipid Nanoparticles in Mice
Advanced Science, EarlyView.This work reveals a novel extracellular nanoparticle transport and metabolic pathway. Following cellular uptake, Food‐grade lipid nanoparticles (FLNs) selectively fuse with lipid droplets (LDs) rather than lysosomes, driving LDs accumulation. This process activates autophagy through the AMPK‐mTOR‐ULK1 signaling axis, facilitating tumor progression ...
Chenglu Peng +10 more
wiley +1 more source
CsA, FK506, corticosteroids and rapamycin inhibit TNFα production by cultured PTEC
, 1993 Benito A. Yard +5 more
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Up-Regulation of Insulin-Like Growth Factor Binding Protein-5 Is Independent of Muscle Cell Differentiation, Sensitive to Rapamycin, But Insensitive to Wortmannin and LY294002 [PDF]
, 1998 S. Rousse
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Advanced Science, EarlyView.Senescent nucleus pulposus cells drive inflammatory M1 macrophage polarization, exacerbating intervertebral disc degeneration (IDD). Conversely, M1 macrophages accelerate NP cell senescence, creating a vicious cycle. iPSCs‐derived mesenchymal stem cell (iMSCs) exosomes break this loop by delivering miR‐100‐5p to suppress mTORC1/glycolysis in ...
Qian Xiang +10 more
wiley +1 more source