Results 281 to 290 of about 315,545 (404)

Rapamycin protects aging muscle

Aging, 2019
Tang, Huibin, Shrager, Joseph B., Goldman, Daniel   +2 more
openaire   +2 more sources

Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases

Nature Reviews Rheumatology, 2016
A. Perl
semanticscholar   +1 more source

Th17 cells favor migration and invasiveness of cervical cancer cells under hypoxia in an IGF2BP2‐dependent manner

International Journal of Cancer, EarlyView.
What's New? Hypoxic regions and inflammatory Th17 cells in the tumor environment are both associated with poor prognosis in cervical cancer. However, synergistic mechanisms between hypoxia and Th17 cells remain elusive. This study demonstrated Th17–hypoxia‐driven mechanisms underlying cervical cancer progression.
Selina Gies, Maike Pohlers, Tanja Tänzer, Emmanuel Ampofo, Matthias W. Laschke, Moritz Schäfer, Yoo‐Jin Kim, Rainer Maria Bohle, Erich‐Franz Solomayer, Konrad Wagner, Martin Empting, Alexandra K. Kiemer, Barbara Walch‐Rückheim   +12 more
wiley   +1 more source

Circular RNA circPLXNC1 functions as an inhibitor of senescence by regulating autophagy in osteoarthritis. [PDF]

Int J Biol Sci
Zhou H, Ji Z, Sun H, Zhang W, Huang Y, Jin G, Cai H, Huang X, Dai J, Zhao J, Chen H, Fan S, Wu Y, Shen J.   +13 more
europepmc   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

Lysosomal and mTORC1 signaling dysregulation underpin the pathology of spastic paraplegia type 80. [PDF]

Nat Commun
Zhi Y, Zhang T, Lu D, Lin S, Su H, Wu Y, Chang Q, Wang S, Lv C, Fu H, Chen LY, Chen WJ, Wang N, Fu Z, Lin X, Xu D.   +15 more
europepmc   +1 more source

Clinical outcomes of patients with metastatic renal cell carcinoma (mRCC) treated with vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) and mammalian target of rapamycin inhibitors (mTORI) after immuno-oncology (IO) checkpoint inhibitors [PDF]

, 2018
Jeffrey Graham, J. Connor Wells, R.R. McKay, Ulka N. Vaishampayan, Aaron R. Hansen, Frede Donskov, Georg A. Bjarnason, Benoit Beuselinck, Guillermo de Velasco, Mei Sheng Duh, Lynn Huynh, R. Chang, Giovanni Zanotti, Krishnan Ramaswamy, Toni K. Choueiri, D.Y.C. Heng   +15 more
openalex   +1 more source

Rapamycin in mice

Aging, 2017
openaire   +2 more sources

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway. [PDF]

Mol Med Rep
Wu Q, Fan J, Sheng Q, He X.
europepmc   +1 more source