Results 351 to 360 of about 315,545 (404)

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Nature, 2009
Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and fruitflies; however, whether inhibition of mTOR signalling can extend lifespan in a mammalian species ...
David E Harrison, Randy Strong, Zelton Dave Sharp   +2 more
exaly   +2 more sources

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Nature Cell Biology, 2004
Estela Jacinto, Robbie J Loewith, Shuo Lin   +2 more
exaly   +2 more sources

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

Nature Medicine, 2002
Markus Guba
exaly   +2 more sources

Solubilization of rapamycin

International Journal of Pharmaceutics, 2001
The solubilization of rapamycin, a poorly water soluble investigational immunosuppressive drug, by facilitated hydrotropy is presented. Partially water-miscible aromatic solutes (such as benzyl alcohol, benzoate, or benzoic acid) can be solubilized by water-miscible cosolvents, such as ethanol and propylene glycol.
P, Simamora, J M, Alvarez, S H, Yalkowsky   +2 more
openaire   +2 more sources